Milli-Mark^® Anti-CD79αcy-PE Antibody, clone HM57

Control
Human Lymphocytes

Evaluated by flow cytometry using human lymphocytes

Milli-Mark Anti-CD79αcy-PE Antibody, clone HM57 is an antibody against CD79αcy for use in FC.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Antibody recognizes Human CD79αcy antigen.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

82-95 kDa (Pilozzi,1998)

CD79 is a disulphide-linked transmembrane heterodimer with a molecular mass of 82-95 kDa belonging to the immunoglobulin superfamily. It comprises the two glycoproteins, CD79α, with a molecular mass of 40-45 kDa, and CD79β, with a molecular mass of 37 kDa. CD79 is non-covalently associated with surface Ig, forming the B-cell receptor complex, which is required for antigen recognition. The expression of CD79 is largely restricted to B-lineage cells (Pilozzi,1998). In precursor B cells, the CD79 protein chains are already expressed in the cytoplasm (CyCD79). Surface expression of CD79 begins at the pro-B cell stage and persists throughout the B-cell differentiation. CD79α is more strongly expressed by B cells in the follicular mantle zone than by germinal centre B cells, suggesting that activation of mature B cells downregulates CD79 expression. CD79 expression ceases around the onset of plasma cell differentiation, with only a proportion of plasma cells containing CD79 (Comans-Bitter, 1997)(Nakamura, 1997). The HM57 antibody was clustered as Anti-CD79αcy at the Fifth International Workship on Human Leucocyte Differentiation Antigens (Engel, 1995).

Synthetic peptide sequence comprising amino acids 202-216 of the CD79α protein. This oligopeptide represents an intra-cytoplasmic C-terminal part of the protein.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Protein A purified

Purified Mouse monoclonal IgG1 conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Maintained refrigerated at 2-8°C from date of receipt. Protected from light in undiluted aliquots for 6 months from date of receipt.

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany