제품 이름
DSPE-PEG(2000) Carboxylic Acid, Avanti Research™ - A Croda Brand 880135P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (880135P-10mg), pkg of 1 × 100 mg (880135P-100mg), pkg of 1 × 25 mg (880135P-25mg), pkg of 1 × 50 mg (880135P-50mg), pkg of 1 × 500 mg (880135P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880135P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCCNC(C/C=C\OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOCCOOCC(O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=
General description
Carboxylic acids are readily soluble in polar solvents such as water and alcohols. DSPE-PEG(2000) carboxylic acid consists of a hydrophilic polyethylene glycol (PEG) chain of 2kDa.
Application
DSPE-PEG(2000) carboxylic acid has been used:
- to covalently conjugate integrin α-2 (ITGA2) antibodies to the surface of the liposomes
- in the preparation of atosiban-conjugated liposomes
- to prepare dual complementary liposome
Biochem/physiol Actions
DSPE-PEG(2000) carboxylic acid increases the blood circulation time of liposomes. The carboxyl group of DSPE-PEG(2000) carboxylic acid aids in covalent conjugation with antibodies.
Packaging
20 mL Clear Glass Screw Cap Vial (880135P-500mg)
5 mL Amber Glass Screw Cap Vial (880135P-100mg)
5 mL Amber Glass Screw Cap Vial (880135P-10mg)
5 mL Amber Glass Screw Cap Vial (880135P-25mg)
5 mL Amber Glass Screw Cap Vial (880135P-50mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Junxue An et al.
Journal of colloid and interface science, 577, 92-100 (2020-05-31)
Phospholipids constitute biocompatible and safe excipients for pulmonary drug delivery. They can retard the drug release and, when PEGylated, also prolong the residence time in the lung. The aim of this work was to assess the structure and coherence of
Mohammad Mashreghi et al.
Nanoscale research letters, 15(1), 101-101 (2020-05-10)
In this study, we have surface-functionalized PEGylated-nanoliposomal doxorubicin (DOX) with anti-EpCAM (epithelial cell adhesion molecule) aptamer via post-insertion of anti-EpCAM aptamer-conjugated DSPE-mPEG2000 into Caelyx® (ED-lip). The size, charge, release profile, and cytotoxicity and cellular uptake of formulation were determined. The
ITGA2 as a potential nanotherapeutic target for glioblastoma
Guo P, et al.
Scientific reports, 9(1), 6195-6195 (2019)