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1.37004

Titriplex^® III

Name: Titriplex<SUP>®</SUP> III
Brand: MM

(ethylene dinitrilo tetraacetic acid disodium salt dihydrate), EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

동의어(들):

Ethylenediaminetetraacetic acid disodium salt dihydrate, Disodium dihydrogen ethylenediaminetetraacetate, Ethylenediaminetetraacetic acid disodium salt, Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na₂, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na₂

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₀H₁₄N₂Na₂O₈ · 2H₂O

CAS 번호:

6381-92-6

Molecular Weight:

372.24

UNSPSC Code:

12352107

EC Index Number:

205-358-3

Beilstein/REAXYS Number:

3900609

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도움 문의

속성

grade

ACS reagent

Quality Segment

500

agency

BP, ChP, JP, Ph. Eur., USP

product line

EMPROVE^® EXPERT

form

solid

feature

RNase and DNase free

technique(s)

in vitro transcription (IVT): suitable

pH

4-5 (20 °C, 50 g/L in H₂O)

mp

248 °C (dec.) (lit.)

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

no temp limit

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

설명

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Titriplex^® III (EDTA, ethylene dinitrilo tetraacetic acid disodium salt dihydrate) is a commonly used chelating agent. As it is capable of forming complexes with divalent metal cations, it can inhibit diverse enzymes that require such cations for activity. It is broadly used as antioxidant in pharmaceutical formulations and cosmetics. The disodium salt provides improved solubility in water compared to standard EDTA.

Due to its low microbial and endotoxin limits, Titriplex^® III (ethylene dinitrilo tetraacetic acid disodium salt dihydrate) Emprove^® Expert is especially suitable for high-risk applications.

Other Notes

Elimination of water of crystallization: 110 °C

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Titriplex is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H332,H373

pcodes

P260 - P271 - P304 + P340 + P312 - P314 - P501

Hazard Classifications

Acute Tox. 4 Inhalation - STOT RE 2 Inhalation

target_organs

Respiratory Tract

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c