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1.37229

Inorganic Pyrophosphatase

EMPROVE® EXPERT

동의어(들):

IPP, PPase

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제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352204
Specific activity:
≥100 units/mL
Assay:
≥95% (SDS-PAGE)
Biological source:
Escherichia coli
Recombinant:
expressed in E. coli
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도움 문의

biological source

Escherichia coli

Quality Segment

500

recombinant

expressed in E. coli

grade

GMP, Halal, Kosher

product line

EMPROVE® EXPERT

assay

≥95% (SDS-PAGE)

form

aqueous solution

specific activity

≥100 units/mL

mol wt

19.7 kDa

technique(s)

in vitro transcription (IVT): suitable

suitability

suitable for (In‑vitro transcription (IVT))

application(s)

pharma/biopharma processes
pharmaceutical

foreign activity

Low endotoxin
Low bioburden
DNase: none detected
RNase: none detected
Nickase: none detected

storage temp.

-10 to -25°C

General description

mRNA therapies represent a revolutionary approach to therapeutics such as vaccines, cancer treatments, and immunotherapies, offering novel ways to treat complex diseases. As a result, global interest in mRNA manufacturing has grown, while regulatory expectations have become increasingly exacting. In this environment, manufacturers require raw materials suitable for pharmaceutical use, ensuring the highest levels of quality and purity for successful mRNA production.

In response, we have developed the high-purity Enzyme Emprove® Expert portfolio, compliant with IPEC-PQG GMP standards, to ensure batch-to-batch consistency in your mRNA manufacturing processes. These critical raw materials are accompanied by comprehensive Emprove® dossiers, providing essential regulatory support to navigate the complexities of the biopharmaceutical industry while ensuring compliance and accelerating time to market.

As part of our SAFC® portfolio, these high-quality raw materials are designed to meet the specific needs of pharma and biopharma production.

Application

Inorganic pyrophosphatase (IPP) is an essential auxiliary enzyme used to enhance the efficiency of in vitro transcription (IVT) reactions for messenger RNA (mRNA) production. During IVT, inorganic pyrophosphate (PPi) accumulates as a reaction by-product and can inhibit RNA polymerase activity, ultimately reducing mRNA yield. IPP catalyzes the hydrolysis of PPi into inorganic phosphate, preventing product inhibition and supporting higher and more consistent transcription efficiency.

Features and Benefits

Our IVT enzyme Emprove® Expert IVT portfolio is designed to align with best-practice IVT methods for mRNA manufacturing and provides all purity requirements for reliable production of mRNA therapeutics and vaccines:
  • High purity (≥95%)
  • Low endotoxin and bioburden
  • DNase and RNase-free
Designed with therapeutic mRNA manufacturing in mind, our range of Emprove® Expert IVT enzymes provide all the quality attributes required for therapeutic mRNA raw materials, with validated quality control testing and manufacturing processes, certifications for AOF, Kosher, and Halal, and an extensive range of quality parameters provided in the COA.

Packaging

137229.0001 / 1 mL / plastic vial

137229.0010 / 10 mL / plastic bottle

137229.0050 / 50 mL / plastic bottle

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

저장 등급

10 - Combustible liquids

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

Emprove® 프로그램을 사용하여 GMP 준수 유지

Emprove® Dossiers로 자격을 가속화하고, 규정 준수를 유지하며, 시간을 절약하세요.

Dossiers 다운로드

주: EmproveSuite.com으로 이동하게 됩니다. 귀하의 사용자 이름과 비밀번호는 시그마알드리치닷컴과는 별개이며 다를 수 있습니다.

무료로 등록하고 몇 분 안에 Emprove® Dossiers에 액세스하세요. 구독 플랜을 업그레이드하여 Emprove® Suite에서 고급 및 맞춤형 콘텐츠를 잠금 해제하세요.

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문서 라이브러리 방문

제품이나 로트/배치 번호를 찾는 데 어려움을 겪고 계신가요?

제품 번호는 웹사이트에 표시될 때 팩 크기/수량과 통합되어 있습니다(예: T1503-25G). 확인하십시오 제품 번호 필드에 해당 제품 번호만 입력하십시오 (예시: T1503).

예:

T1503
제품 번호
-
25G
포장 크기/수량

추가적인 예시:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

입력하기 1.000309185)

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