1.51466
Chromolith® RP-18 endcapped (monolithic) HPLC Columns
L × I.D. 100 mm x 4.6 mm HPLC Columns Validation Kit (3 Columns from 3 different batches)
동의어(들):
Chromolith® Performance RP-18 endcapped 100-4.6 HPLC columns Validation Kit (3 columns from 3 different batches)
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
UNSPSC Code:
41115709
NACRES:
SB.52
Matrix active group:
C18 (RP18), C18 bonding phase
Pore size:
13 nm mesoporosity, 2 μm macroporosity
Matrix:
monolithic silica
제품 이름
Chromolith® RP-18 endcapped, L × I.D. 100 mm x 4.6 mm HPLC columns Validation Kit (3 columns from 3 different batches)
material
PEEK column
Quality Segment
agency
suitable for USP L1
product line
Chromolith®
feature
endcapped
packaging
pkg of 3 ea
extent of labeling
18% Carbon loading
parameter
200 bar pressure, 45 °C max. temp.
technique(s)
HPLC: suitable, LC/MS: suitable, mass spectrometry (MS): suitable (High)
column L × I.D.
10 cm × 4.6 mm
matrix
monolithic silica
matrix active group
C18 (RP18), C18 bonding phase
pore size
13 nm mesoporosity, 2 μm macroporosity
operating pH range
2-7.5
separation technique
reversed phase
storage temp.
no temp limit
General description
Chromolith® Performance RP-18 endcapped 100-4.6 HPLC columns Validation Kit consists of 3 columns from 3 different manufacturing batches. Chromolith® columns are made of monolithic silica with a characteristic bimodal pore structure. Chromolith® Performance RP-18 endcapped columns have macropores with 2 μm diameter, giving a column efficiency exceeding 80,000 plates/meter. The mesopores are 13 nm (130 Å), and the surface modification is octadecylsilane with full end-capping. Chromolith® Performance RP-18 endcapped columns fall under the USP L1 Classification. The column efficiency is comparable to a 5 μm particle size fully porous particulate column. Chromolith® Performance RP-18 endcapped columns are perfectly suitable for LC-MS applications.The column dimension of 100 mm length and 4.6 mm I.D. is the best choice for separations of complex samples on any HPLC System.The revolutionary, monolithic silica with its unique combination of macropores and mesopores enable:
- Rapid separations at very low column back-pressure
- High matrix tolerance, allowing time and cost savings with simplified workflows
- Cost-savings due to extended column lifetimes
- Connection of columns, flow gradients and the use of mobile phases with higher viscosity
Application
- Rapid Determination of 30 Polyphenols in Tongmai Formula: This study utilized the Chromolith® RP-18 endcapped column in a liquid chromatography-tandem mass spectrometry setup to analyze 30 polyphenolic compounds in a traditional Chinese medicine formula, demonstrating its application in pharmaceutical analysis and quality control of complex herbal formulations (Wang et al., 2017).
- Ultra-fast gradient LC method for omeprazole analysis using a monolithic column: The Chromolith® RP-18 endcapped column was employed in an ultra-fast gradient liquid chromatography method for the analysis of omeprazole in enteric-coated pellets, highlighting its efficiency in pharmaceutical quality control and rapid method development (Borges et al., 2010).
Analysis Note
Extent of testing: passes test
Legal Information
Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany
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