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189485

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable

Name: Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable
Brand: MM

The Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

동의어(들):

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable, Ant-A3K/V10F-AIP, Ant-AIP-II, Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH

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크기 선택

보기 변경

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₇₇H₂₉₁N₅₇O₃₉S

Molecular Weight:

3873.63

NACRES:

NA.77

UNSPSC Code:

12352202

Assay:

≥97% (HPLC)

Form:

lyophilized solid

Quality level:

200

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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도움 문의

속성

Quality Level

200

assay

≥97% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

5% acetic acid: 1 mg/mL, water: 1 mg/mL, DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

설명

General description

A highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II) (Cat. No. 189484). AIP-II is an AIP analog where Ala³ and Val¹⁰ are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala²⁸⁶) and KN-93 (Cat. No. 422708). Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cam Kinase-2

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH

Watterson, D.M., et al. 2001. Neurochem. Int.39, 459.
Ishida, A., et al. 1998. FEBS Lett.427, 115.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c