5.08052
iMDK
≥98% (HPLC), solid, midkine inhibitor, Calbiochem®
동의어(들):
Midkine Inhibitor, iMDK, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one, 3-(2-(4-Fluorobenzyl)imidazo[2,1-b][1,3]thiazol-6-yl)-2H-chromen-2-one, MDK Expression Inhibitor
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C21H13FN2O2S
CAS 번호:
Molecular Weight:
376.40
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
제품 이름
Midkine Inhibitor, iMDK,
InChI key
IWFKQTWYILKFGE-UHFFFAOYSA-N
SMILES string
C1=CC=C2C(=C1)C=C(C(=O)O2)C3=CN4C=C(SC4=N3)CC5=CC=C(C=C5)F
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 5 mg/mL
storage temp.
2-8°C
Quality Level
Application
Midkine Inhibitor, iMDK may be used to study its anti-cancer activity on primary effusion lymphoma (PEL) in vitro.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Midkine
Midkine
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
The midkine inhibitor, iMDK, demonstrates strong antiproliferative and antitumor effects both in vitro and in vivo in non-small-cell lung cancer. It also induces apoptosis of primary effusion lymphoma through G2/M cell cycle arrest.
Other Notes
Hao, H., et al. 2013. PLoS ONE8, e71093.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Midkine inhibitor (iMDK) induces apoptosis of primary effusion lymphoma via G2/M cell cycle arrest
Ueno M, et al.
Leukemia Research, 116, 106826-106826 (2022)
Novel midkine inhibitor iMDK inhibits tumor growth and angiogenesis in oral squamous cell carcinoma
Masui M, et al.
Anticancer Research, 36(6), 2775-2781 (2016)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 5.08052.0001 | 04055977242805 |
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