553030
FPS-ZM1
≥98% (HPLC), semisolid,viscous liquid, RAGE antagonist, Calbiochem®
동의어(들):
RAGE Antagonist, FPS-ZM1, Receptor for AGE Antagonist, FPS-ZM1, N-Benzyl-4-chloro-N-cyclohexylbenzamide
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H22ClNO
CAS 번호:
Molecular Weight:
327.85
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
제품 이름
RAGE Antagonist, FPS-ZM1, RAGE Antagonist, FPS-ZM1, is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively, against Aβ40, HMGB1 & S100B, binding to sRAGE).
InChI
1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2
InChI key
XDFKWGIBQMHSOH-UHFFFAOYSA-N
SMILES string
O=C(C1=CC=C(Cl)C=C1)N(CC2=CC=CC=C2)C3CCCCC3
assay
≥98% (HPLC)
form
semisolid
viscous liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
관련 카테고리
Biochem/physiol Actions
Cell permeable: yes
Primary Target
RAGE
RAGE
Reversible: yes
Target Ki: 25, 148, and 230 nM, respectively, against A&beta
Disclaimer
Toxicity: Standard Handling (A)
General description
A blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230 nM, respectively, against Aβ40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Aβ40 and Aβ42 into the brain. Also shown to suppress Aβ-RAGE induced NF-κB activation and NF-κB-dependent transcription of β-secretase. Daily treatment of APPsw/0 murine AD model (1 mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice.
Other Notes
Deane, R., et al. 2012. J. Clin. Invest.122, 1377.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 553030-25MGCN | 04055977193466 |
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