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Merck

565788

β-Secretase Inhibitor IV

≥98% (HPLC), solid, β-secretase inhibitor, Calbiochem®

동의어(들):

β-Secretase Inhibitor IV, BACE Inhibitor C3

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C31H38N4O5S
CAS 번호:
797035-11-1
Molecular Weight:
578.72
UNSPSC Code:
12352200
MDL number:
MFCD09037559
NACRES:
NA.77

주요 문서

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제품 이름

β-Secretase Inhibitor IV, β-Secretase Inhibitor IV, CAS 797035-11-1, is a cell-permeable inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC50 = 15 nM for human BACE-1).

SMILES string

[S](=O)(=O)(N(C)c1cc(cc(c1)C(=O)N[C@H](C)c4ccccc4)C(=O)N[C@H]([C@H](O)CNC3CC3)Cc2ccccc2)C

InChI

1S/C31H38N4O5S/c1-21(23-12-8-5-9-13-23)33-30(37)24-17-25(19-27(18-24)35(2)41(3,39)40)31(38)34-28(16-22-10-6-4-7-11-22)29(36)20-32-26-14-15-26/h4-13,17-19,21,26,28-29,32,36H,14-16,20H2,1-3H3,(H,33,37)(H,34,38)/t21-,28+,29-/m1/s1

InChI key

VPNIQGRFZCTBEZ-SPTGULJVSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

관련 카테고리

Biochem/physiol Actions

Cell permeable: yes
Primary Target
BACE-1 human
Product does not compete with ATP.
Reversible: no
Target IC50: 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 565794).Please note that the molecular weight for this compound is batch-specific due to variable water content.

Other Notes

Halima, S.B., et al. 2016. Cell Reports.14, In press.
Stachel, S.J., et al. 2004. J. Med. Chem.47, 6447.
Solubilize in DMSO (10 mg/ml), aliquot & store at -20*C; stable for 3 months.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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국제 무역 품목 번호

SKUGTIN
565788-1MGCN04055977191820

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