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Merck

AB144

Anti-Choline Acetyltransferase Antibody

CHEMICON®, goat polyclonal

동의어(들):

ChAT

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제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
guinea pig, mouse, rat
Application:
immunohistochemistry
western blot
Technique(s):
immunohistochemistry: suitable
western blot: suitable
Citations:
120
Uniprot accession no.:
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제품 이름

Anti-Choline Acetyltransferase Antibody, serum, Chemicon®

biological source

goat

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

guinea pig, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

Gene Information

mouse ... Chat(12647)
rat ... Chat(290567)

Analysis Note

Control
Rat brain tissue

Application

Anti-Choline Acetyltransferase Antibody is an antibody against Choline Acetyltransferase for use in IH & WB.
Immunoblot: 1:1,000-1:5,000

Immunohistochemistry: 1:500-1:1,000. See page two of this data sheet.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Neuronal & Glial Markers

Biochem/physiol Actions

Recognizes cholinergic neurons in brain and central nervous systems.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

70 kDa
Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-cholinacetyltransferase a useful specific marker.

Immunogen

Human placental enzyme.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Goat antisera, liquid, no preservatives.
Unpurified

Preparation Note

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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저장 등급

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


시험 성적서(COA)

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system.
Stanley, EM; Fadel, J
Synapse null
Sally I Firth et al.
Experimental eye research, 75(1), 49-60 (2002-07-19)
The neuropeptide galanin has not been localized previously in the primate uvea, and the neuropeptide somatostatin has not been localized in the uvea of any mammal. Here, the distribution of galanin-like and somatostatin-like immunoreactive axons in the iris, ciliary body
Jayakrishnan Nair et al.
Respiratory physiology & neurobiology, 236, 57-68 (2016-11-14)
Limited data are available regarding the spinal projections of afferent fibers in the phrenic nerve. We describe a method that robustly labels phrenic afferent spinal projections in adult rats. The proximal end of the cut phrenic nerve was secured in
Melissa A Stouffer et al.
Nature communications, 6, 8543-8543 (2015-10-28)
Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal. However, the rising incidence of obesity, which results in chronically elevated insulin levels, implies that insulin may also act in brain centres that regulate motivation and
Lorelei Stoica et al.
Annals of neurology, 79(4), 687-700 (2016-02-19)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motor neurons, resulting in progressive muscle weakness, paralysis, and death within 5 years of diagnosis. About 10% of cases are inherited, of which 20% are due to

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