제품 이름
Anti-Huntingtin phosphoSer 421 Antibody, Chemicon®, from rabbit
biological source
rabbit
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pSer421)
Quality Level
Gene Information
human ... HTT(3064), SLC6A4(6532)
Application
Detect Huntingtin using this Anti-Huntingtin Antibody, phosphoSer 421 validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Western blotting: 1:500-1:3,000 using ECL. Reacts with the ~190 kD Huntingtin protein in unstimulated human PC-3 whole cell lysate. Additional bands at ~130 may also be detected.
ELISA: 1:10,000-1:40,000
Optimal working dilutions must be determined by the end user.
ELISA: 1:10,000-1:40,000
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Recognizes Huntingtin protein phosphorylated at serine 421.Minimal reactivity is expected with the non-phosphorylated form of the protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Epitope: phosphoSer 421
Synthetic peptide from human Huntingtin protein. It is expected that the antibody may cross react with rat and mouse due to conservation of the immunogen sequence (8/9).
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity purified immunoglobulin. Liquid in 0.02M Potassium phosphate, 0.15M Sodium Chloride with 0.01% sodium azide.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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저장 등급
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Hélène Vitet et al.
eLife, 12 (2023-07-11)
Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains a pool of SVs, only a small fraction of which are released, it has been
Adriana Covarrubias-Pinto et al.
Journal of neuroscience research, 99(1), 223-235 (2020-08-06)
Huntington's disease (HD) is a neurodegenerative disorder caused by a glutamine expansion at the first exon of the huntingtin gene. Huntingtin protein (Htt) is ubiquitously expressed and it is localized in several organelles, including endosomes. HD is associated with a
Kirstie H Stansfield et al.
Toxicological sciences : an official journal of the Society of Toxicology, 127(1), 277-295 (2012-02-22)
Dysregulation of synaptic development and function has been implicated in the pathophysiology of neurodegenerative disorders and mental disease. A neurotrophin that has an important function in neuronal and synaptic development is brain-derived neurotrophic factor (BDNF). In this communication, we examined
Kirstie H Stansfield et al.
Journal of neurochemistry, 131(5), 655-666 (2014-08-08)
High levels of manganese (Mn) exposure decrease striatal medium spiny neuron (MSN) dendritic length and spine density, but the mechanism(s) are not known. The Huntingtin (HTT) gene has been functionally linked to cortical brain-derived neurotrophic factor (BDNF) support of striatal
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| AB9562 | 04053252331145 |
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