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Merck

ABC459

Anti-NOX4 Antibody

from rabbit

동의어(들):

NADPH oxidase 4, Kidney oxidase-1, KOX-1, Kidney superoxide-producing NADPH oxidase, Renal NAD(P)H-oxidase

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제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunohistochemistry
Species reactivity:
human, mouse
Citations:
5
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
Uniprot accession no.:
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제품 이름

Anti-NOX4 Antibody, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

species reactivity (predicted by homology)

rat (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... NOX4(50507)

Analysis Note

Evaluated by Immunohistochemistry in human kidney tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected NOX4 in human kidney tissue.

Application

Anti-NOX4 Antibody is a highly specific rabbit polyclonal antibody, that targets NADPH Oxidase (phox) & has been tested in IHC & ICC.
Immunohistochemistry Analysis: A 1:500 and a 1:50 dilution from a representative lot detected NOX4 in human kidney and skeletal muscle tissues, respectively.

Immunohistochemistry Analysis:: A representative lot detected NOX4 in mouse liver tissue (I. Fabregat, IDIBELL, Barcelona, Spain).

Immunocytochemistry Analysis: A representative lot detected NOX4 in Hep3B cells (Esther Bertran, IDIBELL, Barcelona, Spain).

Immunohistochemistry Analysis: A representative lot detected NOX4 in mouse liver tissues expressing wildtype Mdr2/p19, or knockout Mdr2 ARF or knockout Stat3/Mdr2 (Sancho, P. et al. (2012). PLoS One. 7(9):e45285.).
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

67 kDa calculated
NOX4 (NADPH oxidase 4) is a phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes with resultant antimicrobial activity and has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex.

Immunogen

Linear peptide corresponding to the C-terminus of human NOX4.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified
Protein A purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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저장 등급

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Yung-Chih Chen et al.
Journal of the American Heart Association, 11(1), e022761-e022761 (2022-01-01)
Background Diabetes is known to accelerate atherosclerosis and increase plaque instability. However, there has been a lack of suitable animal models to study the effect of diabetes on plaque instability. We hypothesized that the tandem stenosis mouse model, which reflects
Joaquim Moreno-Càceres et al.
Cell death & disease, 8(10), e3098-e3098 (2017-10-13)
Hepatocellular carcinoma (HCC) is a heterogeneous tumour associated with poor prognostic outcome. Caveolin-1 (CAV1), a membrane protein involved in the formation of caveolae, is frequently overexpressed in HCC. Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine having a dual role
Jin-Ran Chen et al.
JBMR plus, 4(8), e10376-e10376 (2020-08-18)
Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase- (Nox-) dependent accumulation of ROS may be an approach to potentially minimize
Becky A Diebold et al.
Methods in molecular biology (Clifton, N.J.), 1982, 191-229 (2019-06-07)
The identification of NADPH oxidase (NOX) isoforms in tissues is essential for interpreting experiments and for next step decisions regarding cell lines, animal models, and targeted drug design. Two basic methods, immunoblotting and reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR), are

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