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Merck

ABS90

Anti-Notch 1 Antibody, extracellular

from rabbit, purified by affinity chromatography

동의어(들):

Notch homolog 1, translocation-associated (Drosophila), Notch (Drosophila) homolog 1 (translocation-associated), Translocation-associated notch protein TAN-1, neurogenic locus notch homolog protein 1

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

주요 문서

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제품 이름

Anti-Notch 1 Antibody, extracellular, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat

species reactivity (predicted by homology)

canine (91% sequence homology), mouse (97% sequence homology), chimpanzee (92% sequence homology)

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

NP_001099191

UniProt accession no.

Q07008

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... NOTCH1(4851)
rat ... Notch1(25496)

Analysis Note

Control
Human lymph node lysate
Evaluated by Western Blot in human lymph node lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Notch 1 on 10 µg of human lymph node lysate.

Application

Anti-Notch 1 Antibody, extracellular detects level of Notch 1 & has been published & validated for use in WB, IH(P).
Immunohistochemistry Analysis: 1:400 dilution of this antibody has been shown to detect Notch 1 in gastrointestinal and colorectal carcinoma tissue.
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

Biochem/physiol Actions

This antibody recognizes Notch 1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
~260 kDa observed. Notch 1, extracellular is calculated at ~183 kDa

Immunogen

Epitope: Extracellular domain
GST-tagged recombinant protein corresponding to the extracellular domain of rat Notch 1.

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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저장 등급

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Matthew J White et al.
The Journal of cell biology, 222(12) (2023-10-05)
Notch receptors control tissue morphogenic processes that involve coordinated changes in cell architecture and gene expression, but how a single receptor can produce these diverse biological outputs is unclear. Here, we employ a 3D model of a human ductal epithelium
Fernanda Silva et al.
Oncology letters, 12(4), 2686-2691 (2016-10-05)
Epithelial ovarian cancer is the most lethal gynecologic malignancy, despite advances in treatment. The most common histological type, high-grade ovarian serous carcinoma (OSC) is usually diagnosed at an advanced stage, and although these types of tumors frequently respond to surgery

국제 무역 품목 번호

SKUGTIN
ABS9004053252628894

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