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Merck

FCABS400F

Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC

Milli-Mark®, from rabbit

동의어(들):

Fc fragment of IgE high affinity I receptor for gamma polypeptide, Fc-epsilon RI-gamma, FceRI gamma, IgE Fc receptor subunit gamma, Immunoglobulin E receptor, high affinity,gamma chain

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

주요 문서

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제품 이름

Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC, Milli-Mark®, from rabbit

biological source

rabbit

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

isotype

IgG

NCBI accession no.

NP_004097

UniProt accession no.

P30273

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... FCER1G(2207)

관련 카테고리

Application

Milli-Mark Anti-FcεRI Antibody, γ subunit-FITC is an antibody against FcεRI for use in FC.
Research Category
Inflammation & Immunology
Research Sub Category
Inflammation & Autoimmune Mechanisms

Biochem/physiol Actions

Recognizes and is specific for FcεRI, γ-subunit.

Analysis Note

Control
RBL cells
Evaluated by flow cytometry using RBL cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

10 kDa Calculated
Type I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.

Immunogen

Synthetic peptide corresponding to amino acids 80-86 of γ-subunit of Fc receptors.

Other Notes

Optimal working dilutions must be determined by end user for other instruments
Unconjugated antibody (Cat No. 06-727) has been shown to work on Human and Mouse.

Physical form

Protein A purified
Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Preparation Note

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

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저장 등급

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Spandan V Shah et al.
Cell reports, 25(10), 2766-2774 (2018-12-06)
Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg) acquire adaptive features, including robust proliferation, multifunctionality, rapid
Marc Potempa et al.
Journal of immunology (Baltimore, Md. : 1950), 208(7), 1742-1754 (2022-03-25)
Although interactions between inhibitory Ly49 receptors and their self-MHC class I ligands in C57BL/6 mice are known to limit NK cell proliferation during mouse CMV (MCMV) infection, we created a 36-marker mass cytometry (CyTOF) panel to investigate how these inhibitory
James D Dahlvang et al.
Journal of immunology (Baltimore, Md. : 1950), 210(8), 1108-1122 (2023-03-08)
CMV infection alters NK cell phenotype and function toward a more memory-like immune state. These cells, termed adaptive NK cells, typically express CD57 and NKG2C but lack expression of the FcRγ-chain (gene: FCER1G, FcRγ), PLZF, and SYK. Functionally, adaptive NK
Zeguang Wu et al.
Journal of immunology (Baltimore, Md. : 1950), 207(10), 2534-2544 (2021-10-10)
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection promotes NK cells with
Cristina Capuano et al.
Frontiers in immunology, 9, 1031-1031 (2018-06-06)
Natural killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated. Human cytomegalovirus (HCMV) infection profoundly affects NK cell compartment, as
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국제 무역 품목 번호

SKUGTIN
FCABS400F04053252757730

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