P9375
1,10-Phenanthroline monohydrate
reagent grade
동의어(들):
o-Phenanthroline monohydrate
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크기 선택
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H8N2 · H2O
CAS 번호:
Molecular Weight:
198.22
UNSPSC Code:
12352116
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-629-2
Beilstein/REAXYS Number:
4008096
MDL number:
biological source
synthetic (organic)
Quality Level
grade
reagent grade
form
powder
mp
100-104 °C (lit.)
solubility
methanol: 200 mM (Stock solution is stable for months at –20° C.)
SMILES string
O.c1cnc2c(c1)ccc3cccnc23
InChI
1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
InChI key
PPQJCISYYXZCAE-UHFFFAOYSA-N
Gene Information
human ... FNTA(2339)
General description
Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.
Application
1,10-Phenanthroline monohydrate has been used:
- as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells
- as a negative control in in situ zymography of mice heart samples
- in in vitro resveratrol chelation and reducing activities assays to chelate iron
When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.
Biochem/physiol Actions
Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
The transmodulation of HER2 and EGFR by substance P in breast cancer cells requires c-Src and metalloproteinase activation
Garcia-Recio S, et al.
PLoS ONE, 10(6), e0129661-e0129661 (2015)
Electrochemical and DFT study of the reduction of substituted phenanthrolines
Ferreira H, et al.
Polyhedron, 122, 147-154 (2017)
Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans
Soares MV, et al.
Free Radical Research, 52(9), 939-951 (2018)