A2478
APHA Compound 8
solid, ≥98% (HPLC)
동의어(들):
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C16H16N2O3
CAS 번호:
Molecular Weight:
284.31
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
제품 이름
APHA Compound 8, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2
InChI
1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+
InChI key
UFQOXIMRSMFQRI-BQYQJAHWSA-N
Biochem/physiol Actions
HDAC (histone deacetylase) inhibitor.
One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Seiji Kuroda et al.
Molecular therapy. Methods & clinical development, 17, 612-621 (2020-04-18)
Non-toxic herpes simplex virus (HSV) vectors can be generated by functional deletion of all immediate-early (IE) genes, providing a benign vehicle with potential for gene therapy. However, deletion of multiple IE genes raises manufacturing concerns and thus limits clinical application