Resveratrol

Selective inhibitor of COX−1.

Resveratrol has been used:

• in entrapment experiment
• to study its neuroprotective effect on retinal neuronal cell death mediated by diabetes-induced activation of Ca²⁺/calmodulin-dependent protein kinase II
• as a standard in the assessment of stilbene content in grapevine leaf by in vivo fluorometry

Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD⁺)-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-g-activated receptor coactivator-1a (PGC-1a) and FOXO (forkhead box) activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation. Resveratrol has antiviral action against Herpes simplex virus-1 (HSV1) and HSV2. It also exhibits antitumor and phytoestrogenic biological activities. Resveratrol is known to prolong life in many species by mediating several physiological events.

Soluble in ethanol, DMSO, and acetone. Only very slightly soluble in water (3 mg/100 mL).