L7895
Lipopolysaccharides from Salmonella typhosa
γ-irradiated, BioXtra, suitable for cell culture
Synonym(s):
LPS
biological source
bacterial (Salmonella typhosa)
sterility
γ-irradiated
product line
BioXtra
form
lyophilized powder
purified by
gel-filtration chromatography
technique(s)
cell culture | mammalian: suitable
impurities
<1% Protein (Lowry)
color
white to faint yellow
solubility
water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
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Application
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Lipopolysaccharides from Salmonella typhosa are used in cell culture and cell binding applications. The role of LPS in the secretion of TNF-α and IL-6 was studied in mouse spleen cell culture. It was used to study the role of inflammatory responses in multiple sclerosis.
Biochem/physiol Actions
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Other Notes
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Joanne L Jones et al.
Brain : a journal of neurology, 133(Pt 8), 2232-2247 (2010-07-28)
Treatment of early relapsing-remitting multiple sclerosis with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath [registered trade mark]) significantly reduced the risk of relapse and accumulation of disability compared with interferon β-1a in a phase 2 trial [Coles et al., (Alemtuzumab
Yasuhisa Ano et al.
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The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the
Yasuhisa Ano et al.
Molecules (Basel, Switzerland), 24(3) (2019-01-31)
Inflammation in the brain is associated with various disorders including Alzheimer's disease and depression. Thus, inflammation has received increasing attention regarding preventive approaches to such disorders. Epidemiological investigations have reported that drinking tea reduces the risk of dementia and depression.
Aurélien Godinat et al.
Current protocols in chemical biology, 6(3), 169-189 (2014-09-11)
The great complexity of many human pathologies, such as cancer, diabetes, and neurodegenerative diseases, requires new tools for studies of biological processes on the whole organism level. The discovery of novel biocompatible reactions has tremendously advanced our understanding of basic
D N Dao et al.
Infection and immunity, 72(4), 2067-2074 (2004-03-25)
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as a virulence factor of Mycobacterium tuberculosis, and modification of the terminal arabinan residues of this compound with mannose caps (producing mannosyl-capped LAM [ManLAM]) in M. tuberculosis or with phosphoinositol
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