Tangential Flow Filtration Systems and Holders
Our tangential flow filtration (TFF) systems and holders support reliable concentration, ultrafiltration, and diafiltration from lab-scale to full manufacturing. Designed for bioprocessing, our solutions help maximize yield, maintain product integrity, and streamline scale-up. With options for single-use or multi-use configurations and compatibility with closed processing, our solutions enable efficient, contamination-controlled workflows.
Key benefits and features
Designed to preserve the nature and activity of biomolecules and maximize product yield through optimized drainability, tank design and components selection
Single- or multi-use systems scalable from process development to manufacturing in open and closed processing modes.
Efficient and scalable TFF solutions
Tangential flow filtration systems improve process efficiency while protecting sensitive biomolecules. Our scalable design supports consistent performance throughout development, reduces risk and accelerates tech transfer. Flexible configurations enable integration into diverse workflows, with single-use or reusable options for open or closed processing, streamlining operations and optimizing resource use. We offer comprehensive application support and documentation to aid process optimization, troubleshooting, and regulatory readiness, supporting faster development and smoother scale-up.
TFF solutions for single- and multi-use processes
Process-scale single-use TFF systems
Mobius® TFF 20 and 80 systems are a family of single use systems designed for efficient concentration and diafiltration of proteins. They offer two system scales, modular tank sizes, a flowpath option to match Pellicon® devices and capsules, and can operate in either open or closed mode.
Process-scale multi-use TFF systems and holders
The fully automated Cogent® Process-scale TFF system is designed to separate and purify monoclonal antibodies, vaccines, plasma, and therapeutic proteins. It is ideally suited for both pilot and production scale applications, thereby supporting rapid scale-up from small to large-scale operations. Configuration options for SPTFF (Single Pass TFF) applications can also be proposed to address process intensification needs.
Process development multi-use TFF systems and holders
The Cogent® Lab TFF system family uses similar design, sensing technologies, and accessories as our manufacturing-scale equipment. It is optimized for high product recovery and drainability, ensuring successful small-scale TFF operations.
Common Control Platform® (CCP®)
Common Control Platform® (CCP®) is a common software platform across our family of fully automated systems. It controls bioprocessing operations, simplifies software management, and securely manages data. Designed to operate in GMP environments, it is developed in line with GAMP® 5 recommendations for automation software and facilitates 21 CFR Part 11 compliance for electronic records and signatures.
Bioprocessing development expertise and support
We bring together bioprocessing expertise, manufacturing technologies, and global infrastructure to support your process development and manufacturing needs, including cell culture, media and buffer preparation, and bioconjugation optimization. Learn more on how we can support you from facility design to implementation.
Frequently asked questions
What are the benefits of a single-use TFF system?
The benefits of single-use TFF systems include faster start-up and turnaround, reduced cleaning and validation requirements and lower cross-contamination risk. TFF single-use systems simplify compliance, reduce water and energy use, and also enhance flexibility in facility design to minimize capital footprint in high-purity operations showing high-changeover applications.
How do I select the right scale?
Share your processing parameters with us. What are your starting and final volume, cross flow rate, membrane area, mode of operation and our experts will guide you to the system that fits your needs.
How can you support me to go faster?
Our Emprove® dossiers gather all the information you need to set up a new product in your system; our validation services support you in validating the installation and performance of your system.
What automation environment do you support?
We offer several automation levels that can be proposed including PLC/HMI powered by CCP®, or headless I/O systems with DCS integration capabilities for Process scale TFF systems. At process development scale, Bio4C® ProcessPad software provides real-time monitoring and control of all Cogent® Lab Systems, with an intuitive user interface that lets you operate the systems with minimal training.
Related webinars
Many factors contribute to a TFF system design; this webinar explains how to optimize the TFF process parameters to achieve superior product quality, consistent and high product yield, high concentration, and reproducible process flux and time.
This webinar discusses how to evaluate retentate recycle tank performance and how an active retentate mixing step can best enable optimum performance of protein concentration / diafiltration in single-use systems.
This webinar discusses the implementation of closed processing for downstream applications and present the design and performance testing of a single-use manufacturing-scale tangential flow filtration system to be able to operate in both functionally and fully closed mode.
Related articles
- There are many options for tangential flow filtration (TFF) in downstream bioprocessing from multi-use to single-use TFF or batch TFF and single-pass TFF.
- Find best practices for using Pellicon® Capsules in ADC processing as well as data from two studies using Pellicon® Capsules and Pellicon® cassettes in the ADC manufacturing process.
- Get practical guidance on using single-pass tangential flow filtration in your downstream process and scaling between capsules and cassettes.
- Learn strategies for designing flexible, modular biomanufacturing facilities, and how single-use technologies and automation enable scalable production.
- Learn what to include in User Requirement Specifications (URS) and how it supports design, qualification, and regulatory compliance for scalable single-use downstream processing systems.
- Explore computer system validation (CSV) in pharma, including core requirements, data integrity, risk management, best practices, and the shift to CSA.
Related resources
- Data sheet: Mobius® TFF 20 System
Single-use tangential flow filtration solution, designed for optimal performance
- Performance guide: Mobius® TFF 20 System for tangential flow filtration
This performance guide is a reference document that provides highlights of key performance aspects of the Mobius® TFF 20 solution with single-use Flexware® assemblies for tangential flow filtration (TFF).
- Data sheet: Mobius® TFF 80 System
Single-use tangential flow filtration solution that offers flexible operating modes and is designed for large-scale processing.
- Performance guide: Mobius® TFF 80 System
This guide includes information from a number of applications and case studies that were designed and/or selected to provide a diverse overview of the system performance under a range of expected processing conditions.
- Spare parts list: Mobius® TFF 80 System
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
- Data sheet: Cogent® process-scale tangential flow filtration system
Fully automated, configurable systems for biopharmaceutical manufacturing and cGMP process scale applications
- Data sheet: Cogent® lab systems
A family of modular and flexible systems for TFF at process development scale
- Spare parts list: Cogent® Lab Systems
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
- Application note: Running a TFF optimization study with Cogent® Lab Systems and Bio4C® Control Software
This application note describes the recommended methods and techniques for optimizing a tangential flow filtration (TFF) process using a Cogent® Lab System.
- Brochure: Process development and drug manufacturing: support services
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
- Application note: closed tangential flow filtration processing at benchtop scale with Mobius® Assemblies
Mobius® Assemblies offer a customizable, closed processing option for tangential flow filtration (TFF) operations.
