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Merck

75892

α-Ketoglutaric acid disodium salt dihydrate

≥98.0% (dried material, NT)

Sinónimos:

2-Oxoglutaric acid disodium salt, Sodium α-ketoglutarate dibasic

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About This Item

Fórmula lineal:
NaOOCCH2CH2COCOONa · 2H2O
Número CAS:
1282616-74-3
Peso molecular:
226.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
57652590
EC Number:
206-167-8
Beilstein/REAXYS Number:
5658566
MDL number:
MFCD00150702

Nombre del producto

α-Ketoglutaric acid disodium salt dihydrate, ≥98.0% (dried material, NT)

InChI key

HSSWOFWCOAQLHZ-UHFFFAOYSA-L

InChI

1S/C5H6O5.2Na.2H2O/c6-3(5(9)10)1-2-4(7)8;;;;/h1-2H2,(H,7,8)(H,9,10);;;2*1H2/q;2*+1;;/p-2

SMILES string

O.O.[Na+].[Na+].[O-]C(=O)CCC(=O)C([O-])=O

assay

≥98.0% (dried material, NT)

form

powder

impurities

~16% water

functional group

ketone

Quality Level

200

Categorías relacionadas

Application

α-Ketoglutaric acid disodium salt dihydrate (2-Oxoglutaric acid disodium salt) may be used as starting reagent for the synthesis of deuteriated 2-oxo[3,3-2H2]glutarate disodium salt.
α-Ketoglutaric acid disodium salt dihydrate is suitable reagent used in a study to investigate the role of nitric oxide (NO) in mast cell physiology and biochemistry.

General description

α-Ketoglutaric acid disodium salt dihydrate (2-Oxoglutaric acid disodium salt) is the hydrated disodium salt of 2-oxoglutaric acid.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCN8267
BCCN6048
BCCM9326
BCCL5657
BCCM6264

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Kisakurek MV.
Hominatio: An International Tribute to Albert Eschenmoser, 2557-2557 (2001)
Piotr Dobrowolski et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 556-561 (2012-12-12)
Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely
E Tomaszewska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(5), 547-554 (2012-12-06)
The potential effects of prenatal administration of dexamethasone (DEX) and postnatal treatment with 2-oxoglutaric acid (2-Ox) on postnatal development of connective tissue of farm animals were not examined experimentally. The aim of this study was to establish changes in morphological
Vivian R Moure et al.
Journal of bacteriology, 195(2), 279-286 (2012-11-13)
Fe protein (dinitrogenase reductase) activity is reversibly inactivated by dinitrogenase reductase ADP-ribosyltransferase (DraT) in response to an increase in the ammonium concentration or a decrease in cellular energy in Azospirillum brasilense, Rhodospirillum rubrum, and Rhodobacter capsulatus. The ADP-ribosyl is removed
R V Durán et al.
Oncogene, 32(38), 4549-4556 (2012-10-23)
Hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are α-ketoglutarate (αKG)-dependent dioxygenases that function as cellular oxygen sensors. However, PHD activity also depends on factors other than oxygen, especially αKG, a key metabolic compound closely linked to amino-acid metabolism. We examined the
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