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Merck

P63204

2,3-Pyridinedicarboxylic acid

99%

Sinónimos:

Quinolinic acid

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About This Item

Fórmula empírica (notación de Hill):
C7H5NO4
Número CAS:
89-00-9
Peso molecular:
167.12
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24278005
EC Number:
201-874-8
Beilstein/REAXYS Number:
137110
MDL number:
MFCD00006295

Nombre del producto

2,3-Pyridinedicarboxylic acid, 99%

InChI key

GJAWHXHKYYXBSV-UHFFFAOYSA-N

InChI

1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)

SMILES string

OC(=O)c1cccnc1C(O)=O

assay

99%

form

powder

mp

188-190 °C (dec.) (lit.)

Quality Level

100

Gene Information

rat ... Gria1(50592), Grin2a(24409)

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Categorías relacionadas

Application

Inhibits glucose synthesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
WXBF6484V
MKCW5881
WXBD9442V
MKCR9642
MKCP0259

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Dorit Cohen-Carmon et al.
Molecular neurobiology, 57(3), 1768-1777 (2019-12-14)
Huntington's disease (HD) is a neurodegenerative late-onset genetic disorder caused by CAG expansions in the coding region of the Huntingtin (HTT) gene, resulting in a poly-glutamine (polyQ) expanded HTT protein. Considerable efforts have been devoted for studying HD and other
L Garcia-Salguero et al.
Archives internationales de physiologie, de biochimie et de biophysique, 99(3), 237-242 (1991-06-01)
The in vitro and in vivo effects of several different inhibitors of carbohydrate metabolism have been studied. The in vitro addition of 5-methoxyindole-2-carboxylic acid (MICA), pent-4-enoic acid, and quinolinic acid to the perfusion medium significantly inhibited liver gluconeogenesis in 48-hour-starved
F Moroni et al.
Journal of neurochemistry, 47(6), 1667-1671 (1986-12-01)
Quinolinic acid (QUIN), an excitotoxic tryptophan metabolite, has been identified and measured in human cerebrospinal fluid (CSF) using a mass-fragmentographic method. Furthermore, its content has been evaluated in frontal cortex obtained at autopsy from the cadavers of patients who died
Gilles J Guillemin
The FEBS journal, 279(8), 1356-1365 (2012-01-18)
Over the last two decades, evidence for the involvement of quinolinic acid (QUIN) in neuroinflammatory diseases has been exponentially increasing. Within the brain, QUIN is produced and released by infiltrating macrophages and activated microglia, the very cells that are prominent
Valéry Combes et al.
Trends in parasitology, 28(8), 311-319 (2012-06-26)
Homeostasis implies constant operational defence mechanisms, against both external and internal threats. Infectious agents are prominent among such threats. During infection, the host elicits the release of a vast array of molecules and numerous cell-cell interactions are triggered. These pleiomorphic
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