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Fórmula empírica (notación de Hill):
C47H86NO13P
Número CAS:
Peso molecular:
904.16
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
Servicio técnico
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Permítanos ayudarledescription
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol (ammonium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850144P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850144P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
O[C@H]1[C@@H]([C@H](O)[C@H](O)[C@@H](O)[C@@H]1O)OP(OC[C@H](OC([C19H31])=O)COC(CCCCCCCCCCCCCCCCC)=O)([O-])=O.[NH4+]
General description
Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Application
18:0-20:4 PI or 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol (ammonium salt) has been used:
- as a negative control to evaluate the specificity of the interaction between cholesterol sulfate and receptor Mincle by surface plasmon resonance (SPR) experiment
- as a test lipid in liposomes harboring candidate triggering receptor expressed on myeloid cells 2 (TREM2) ligands, to assess TREM2 stimulation
- as a reference in liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis to identify PI(18:0/20:4) in cancer tissue-originated spheroids (CTOSs) extraction
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (850144P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850144P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Clase de almacenamiento
11 - Combustible Solids
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Takanori Hiraide et al.
Scientific reports, 6, 29935-29935 (2016-07-21)
Accumulating evidence indicates that cancer cells show specific alterations in phospholipid metabolism that contribute to tumour progression in several types of cancer, including colorectal cancer. Questions still remain as to what lipids characterize the outer edge of cancer tissues and
Alexey V Kostarnoy et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(13), E2758-E2765 (2017-03-16)
Sterile (noninfected) inflammation underlies the pathogenesis of many widespread diseases, such as allergies and autoimmune diseases. The evolutionarily conserved innate immune system is considered to play a key role in tissue injury recognition and the subsequent development of sterile inflammation;
Alicia A Nugent et al.
Neuron, 105(5), 837-854 (2020-01-07)
Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin phagocytosis, but its role in microglial lipid metabolism is unknown. Combining chronic demyelination paradigms and cell sorting with RNA