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Fórmula empírica (notación de Hill):
C45H94N3O19P3
Número CAS:
Peso molecular:
1074.16
MDL number:
UNSPSC Code:
51191904
NACRES:
NA.25
Servicio técnico
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Permítanos ayudarledescription
1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 μg (with stopper and crimp cap (850155P-100ug)), pkg of 1 × 500 μg (with stopper and crimp cap (850155P-500ug))
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+].[NH4+]
General description
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Phosphatidylinositol is a structural phospholipid. Phosphatidylinositol phosphate (PIP) is located in the plasma membrane.
Application
18:1 PI(4,5)P2 is suitable to use as a supplement in native macrophage membranes to generate phospholipid enriched membrane liposome.s It has also been used:
- in the preparation of anionic phospholipid liposomes
- as a component in supported membrane tube (SMrT) templates
- in liposome preparation
Biochem/physiol Actions
Phosphatidylinositol bisphosphate (PIP2) can effectively stimulate the ATPase.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
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Phosphatidylinositol Turnover and Receptors
Ramazzotti G, et al.
Archives of Biochemistry and Biophysics (2016)
Use of the supported membrane tube assay system for real time analysis of membrane fission reactions
Dar S, et al.
Nature Protocols, 12(2), 390-390 (2017)
Dissociation of Rac1 (GDP)-RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3, 4, 5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP
Ugolev Y, et al.
The Journal of Biological Chemistry, 283(32), 22257-22271 (2008)