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Merck

890810P

Avanti

18:0 DDAB

Avanti Research - A Croda Brand

Sinónimos:

Dimethyldioctadecylammonium (Bromide Salt)

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Fórmula empírica (notación de Hill):
C38H80NBr
Número CAS:
Peso molecular:
630.95
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
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assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (890810P-1g), pkg of 1 × 200 mg (890810P-200mg), pkg of 1 × 25 mg (890810P-25mg), pkg of 1 × 500 mg (890810P-500mg)

manufacturer/tradename

Avanti Research - A Croda Brand

application(s)

vaccine development

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCCCC[N+](CCCCCCCCCCCCCCCCCC)(C)C.[Br-]

InChI

1S/C38H80N.BrH/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(3,4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2;/h5-38H2,1-4H3;1H/q+1;/p-1

InChI key

PSLWZOIUBRXAQW-UHFFFAOYSA-M

General description

18:0 DDAB is cationic lipid and a quaternary ammonium salt. The hydrocarbon tails are saturated unlike the ionizable lipids.

Application

18:0 DDAB is suitable for the preparation of lipid-nanoparticles. It has also been used as an adjuvant and combined with monophosphoryl lipid A (MPL) for immunizing mice.

Biochem/physiol Actions

18:0 DDAB is a surface-active molecule, used as an adjuvant to induce systemic immune response. It is non-toxic.

Packaging

5 mL Amber Glass Screw Cap Vial (890810P-200mg)
20 mL Clear Glass Screw Cap Vial (890810P-1g)
5 mL Amber Glass Screw Cap Vial (890810P-25mg)
20 mL Clear Glass Screw Cap Vial (890810P-500mg)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Lipophilic quaternary ammonium salt acts as a mucosal adjuvant when co-administered by the nasal route with vaccine antigens
Klinguer C, et al.
Vaccine, 19(30), 4236-4244 (2001)
Ana Cristina Norberto Oliveira et al.
ACS applied materials & interfaces, 6(9), 6977-6989 (2014-04-10)
This study describes a novel liposomal formulation for siRNA delivery, based on the mixture of the neutral lipid monoolein (MO) and cationic lipids of the dioctadecyldimethylammonium (DODA) family. The cationic lipids dioctadecyldimethylammonium bromide (DODAB) and chloride (DODAC) were compared in
Hong Yu et al.
Infection and immunity, 80(4), 1510-1518 (2012-02-01)
Major impediments to a Chlamydia vaccine lie in discovering T cell antigens and polarizing adjuvants that stimulate protective immunity. We previously reported the discovery of three T cell antigens (PmpG, PmpF, and RplF) via immunoproteomics that elicited protective immunity in