Anti-CENP-A Antibody

17kDa

CENP-A is a variant version of histone H3 found only at centromeres.

Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.

peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A

Anti-CENP-A Antibody is a Rabbit Polyclonal Antibody for detection of CENP-A also known as Centromere autoantigen A & has been tested in WB.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Broad species cross-reactivity is predicted.

CENP-A

Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.

ImmunoAffinity Purified

Stable for 1 year at 2 to 8ºC from date of receipt.

Control
Control Histones (from Hela cells) colcemid-treated or untreated

routinely evaluated by immunoblot in acid extracted histones from HeLa cells

Replaces: 04-205

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