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NADPH, Tetrasodium Salt

Name: NADPH, Tetrasodium Salt
Brand: MM

A ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes.

Sinónimos:

NADPH, Tetrasodium Salt, β-Nicotinamide-adenine Dinucleotide Phosphate, Reduced, 4Na

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Fórmula empírica (notación de Hill):

C₂₁H₂₆N₇O₁₇P₃ · 4Na

Número CAS:

2646-71-1

Peso molecular:

833.35

MDL number:

MFCD00674870

UNSPSC Code:

41106305

NACRES:

NA.51

Assay:

≥90% (HPLC), ≥93% (enzymatic)

Form:

solid

Solubility:

water: 50 mg/mL

Storage temp.:

−20°C

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Propiedades

Quality Level

100

description

Merck USA index - 14, 6348

assay

≥90% (HPLC), ≥93% (enzymatic)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

yellow

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

[P](=O)(O[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O[P](=O)(O)O)[n]4c5ncnc(c5nc4)N)O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=C(CC=C2)C(=O)N)O

InChI

1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

ACFIXJIJDZMPPO-NNYOXOHSSA-N

Descripción

General description

A ubiquitous coenzyme that acts as an electron donor in many reactions utilizing dehydrogenase and reductase enzymes. It is generated by reduction of the electron acceptor NADP⁺. The following biological pathways involve NADPH: formation of carbohydrate from CO₂ during photosynthesis, maintenance of high levels of reduced glutathione in erythrocytes, reduction of thioredoxin.

Application

NADPH, tetrasodium salt, has been used:

as a cofactor in the enzymatic synthesis of epoxidized metabolites from polyunsaturated fatty acids, facilitating the epoxidation reaction catalyzed by the cytochrome P450 enzyme BM3
in microsomal assays to evaluate the metabolic stability of CHD1L inhibitors
in conjunction with glutathione to reduce S-glutathionylated cysteine groups during the biotin switch assay, facilitating the detection of protein S-glutathionylation in the study of HLTF-deleted colorectal cancer models

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c