MABN511
Anti-SUR2B Antibody, clone N323A/31
clone N323/A31, from mouse
別名:
ATP-binding cassette sub-family C member 9, Sulfonylurea receptor 2
ログインで組織・契約価格をご覧ください。
サイズを選択してください
表示を変更する
この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
N323/A31, monoclonal
species reactivity
mouse, rat, human
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
rat ... Abcc9(25560)
General description
Sulfonylurea receptor 2 (Sur2), also known as ATP-binding cassette sub-family C member 9 (ABCC9), belongs to the ATP-binding cassette transporter (ABC transporter) superfamily. Sur2 is a subunit of ATP-sensitive potassium channels (KATP). The potassium channel, inwardly rectifying subfamily J member 11 (KCNJ11) interacts with Sur2 in the formation of cardiac and smooth muscle-type KATP channels, where Sur2 is required for activation and regulation of the channel. Sur2 is expressed at high levels in heart, skeletal muscle and ovary, and at moderate levels in brain, tongue and pancreatic islets. Expression in other tissue is at low levels. Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2), diabetes mellitus permanent neonatal (PNDM), as well as transient neonatal diabetes mellitus type 3 (TNDM3). Sur2B is an alternatively spliced isoforms of Sur2 (Sur2A), having differences in the amino acid sequence (1504-1545).
~58 kDa observed. The calculated molecular weight is 175 kDa However, this protein may be observed at 58 kDa due to proteolytic cleavage (Prof. J. Trimmer, University of California, Davis.).
Immunogen
Recombinant protein corresponding to the cytoplasmic domain of the cleaved form of rat SUR2.
Application
Anti-SUR2B Antibody, clone N323A/31 is a highly specific mouse monoclonal antibody, that targets SUR & has been tested in western blotting & IHC.
Western Blotting Analysis: 1 µg/mL from a representative lot detected the cleaved form of SUR2B in mouse brain tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected the cleaved form of SUR2B in rat skeletal muscle tissue.
Western Blotting Analysis: A representative lot detected SUR2B in wild type mouse heart tissue lysate, and demonstrated a loss of signal in SUR2B knock out mouse heart tissue lysate (Prof. J. Trimmer, University of California, Davis.).
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected the cleaved form of SUR2B in rat skeletal muscle tissue.
Western Blotting Analysis: A representative lot detected SUR2B in wild type mouse heart tissue lysate, and demonstrated a loss of signal in SUR2B knock out mouse heart tissue lysate (Prof. J. Trimmer, University of California, Davis.).
Biochem/physiol Actions
This antibody recognizes the cytoplasmic domain of the cleaved form of SUR2B. This antibody may cross react with SUR1 based upon 75% sequence homology.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in human kidney tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected the cleaved form of SUR2B in 10 µg of human kidney tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected the cleaved form of SUR2B in 10 µg of human kidney tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Still not finding the right product?
製品選択ツール}で選択肢を絞り込んでください。
保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
MABN511:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。