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Merck

14510

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid

≥96.0% (HPLC)

Sinónimos:

BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid

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About This Item

Fórmula empírica (notación de Hill):
C22H24N2O10
Número CAS:
85233-19-8
Peso molecular:
476.43
UNSPSC Code:
12352112
NACRES:
NA.22
PubChem Substance ID:
329750514
MDL number:
MFCD00036255
Beilstein/REAXYS Number:
5192406

Nombre del producto

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid, ≥96.0% (HPLC)

InChI

1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32)

SMILES string

OC(=O)CN(CC(O)=O)c1ccccc1OCCOc2ccccc2N(CC(O)=O)CC(O)=O

InChI key

FTEDXVNDVHYDQW-UHFFFAOYSA-N

assay

≥96.0% (HPLC)

form

powder

fluorescence

λex 251 nm; λem 363 nm
λex 274 nm; λem 363 nm (With Calcium)

functional group

amine
carboxylic acid

storage temp.

2-8°C

Quality Level

200

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Application

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′′-tetraacetic acid was used for the spectrophotometric monitoring of Ca2+ levels. It may be used as chelator of cytosolic Ca²+ to investigate the effect of methoxychlor on cytosolic free Ca²+ concentrations and apoptosis in HA59T human hepatoma cells.
Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels

General description

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid is a highly selective calcium chelating reagent. Effect of microinjected calcium-loaded 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (CaBAPTA) on cell-to-cell diffusion of carboxyfluorescein has been studied in staminal hairs of Setcreasea purpurea. It is reported to be a metabolite of 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetra(acetoxymethyl ester) (BAPTA-AM) in rat urine.
pH 8.0 Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCN6910
BCCL7775
BCCK6787
BCCG9973
BCCJ4976

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Chi-Ting Horng et al.
The Chinese journal of physiology, 58(1), 1-8 (2015-02-18)
Methoxychlor, an organochlorine pesticide, is thought to be an endocrine disrupter that affects Ca²⁺ homeostasis and cell viability in different cell models. This study explored the action of methoxychlor on cytosolic free Ca²⁺ concentrations ([Ca²⁺]i) and apoptosis in HA59T human
E B Tucker
Planta, 182(1), 34-38 (1990-08-01)
The effect of microinjected calcium-loaded 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid (CaBAPTA) on cell-to-cell diffusion of carboxyfluorescein (CF) was examined in staminal hairs of S. purpurea Boom. The CaBAPTA was microinjected into the cytoplasm of the staminal hairs either with CF or prior
B E Britigan et al.
Biochemical pharmacology, 55(3), 287-295 (1998-03-04)
A role for increases in intracellular calcium (Ca2+) has been suggested in the pathophysiology of various forms of oxidant-mediated cell injury. In recent studies, we found that iron bound to the Pseudomonas aeruginosa siderophore, pyochelin, augments oxidant-mediated endothelial cell injury
Determination of 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid (BAPTA free acid) in rat plasma, urine and feces by liquid chromatography with UV and tandem mass spectrometric detection.
Feng Z and Wenying L.
Journal of Chromatography. B, Biomedical Applications, 878(30), 3052-3058 (2010)
Mayeul Collot et al.
Journal of the American Chemical Society, 134(36), 14923-14931 (2012-07-24)
We designed Calcium Rubies, a family of functionalizable BAPTA-based red-fluorescent calcium (Ca(2+)) indicators as new tools for biological Ca(2+) imaging. The specificity of this Ca(2+)-indicator family is its side arm, attached on the ethylene glycol bridge that allows coupling the
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