19215
Butyric acid
analytical standard
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Fórmula lineal:
CH3CH2CH2COOH
Número CAS:
Peso molecular:
88.11
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-532-3
Beilstein/REAXYS Number:
906770
MDL number:
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Permítanos ayudarleInChI key
FERIUCNNQQJTOY-UHFFFAOYSA-N
InChI
1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)
SMILES string
CCCC(O)=O
grade
analytical standard
vapor density
3.04 (vs air)
vapor pressure
0.43 mmHg ( 20 °C)
assay
≥99.5% (GC)
autoignition temp.
824 °F
shelf life
limited shelf life, expiry date on the label
expl. lim.
10 %
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
refractive index
n20/D 1.398 (lit.)
bp
162 °C (lit.)
mp
−6-−3 °C (lit.)
density
0.964 g/mL at 25 °C (lit.)
application(s)
cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
format
neat
Quality Level
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General description
Butyric acid is a four-carbon containing, saturated short-chain fatty acid. It commonly occurs in its ester form in animal-based fats and plant-based oils. It is a potent differentiation agent for cells and also possesses antiproliferative activity. In cultured mammalian cells, it affects growth rate, morphology, and gene expression. It also induces apoptosis.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here
Application
This analytical standard can also be used as follows:
- Development and validation of a high-performance liquid chromatographic (HPLC) method combined with UV detection to determine four short-chain fatty acids— formic acid, acetic acid, propionic acid, and butyric acid, and lactic acid in bacterial culture samples after their liquid-liquid extraction (LLE)
- Simultaneous analysis of 10 volatile and non-volatile organic acids in 18 samples of Korean traditional fermented soybean paste, doenjang, by HPLC combined with refractive index detector and gas chromatography coupled with flame ionization detector (GC-FID)
- Determination of butyric, lactic, acetic, and propionic acids in sour cassava starch waste-water samples by reversed-phase high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE), both coupled with diode array detection (DAD)
- Multi-residue analysis of six short-chain fatty acids— acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid, in biological samples of mice colon content by a gas chromatographic method combined with flame ionization detector (GC-FID)
- Packed-fiber solid phase extraction (PFSPE) of eight short-chain fatty acids using polypyrrole nanofibers, from urine samples of children for quantification by gas chromatography-mass spectrometry (GC-MS)
- Multi-residue analysis of 76 volatile compounds from jujube extract samples by gas chromatography-mass spectrometry (GC-MS) after their extraction by steam distillation combined with drop-by-drop extraction
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
161.6 °F - closed cup
flash_point_c
72 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Butyric acid: a small fatty acid with diverse biological functions.
K N Prasad
Life sciences, 27(15), 1351-1358 (1980-10-13)
H M Chen et al.
Clinical chemistry, 35(1), 74-76 (1989-01-01)
We describe a procedure for preparing fecal samples for determination of volatile fatty acids (VFAs) by gas-liquid chromatography (GLC) and "high-performance" liquid chromatography (HPLC). The simple, one-step procedure involves only ultrafiltration through a membrane with a molecular-mass cutoff of 3000
Amita Patnaik et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 8(7), 2142-2148 (2002-07-13)
Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), has demonstrated greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA in preclinical
Gili Berkovitch et al.
Journal of medicinal chemistry, 51(23), 7356-7369 (2008-11-15)
Multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid in cancer cell lines inhibited the proteasome and induced apoptosis and heme synthesis. The most potent prodrug was butyryloxymethyl 5-amino-4-oxopentanoate (1a). The metabolically released formaldehyde from the prodrugs was the dominant factor affecting
Shomik Sengupta et al.
Journal of gastroenterology and hepatology, 21(1 Pt 2), 209-218 (2006-02-08)
Butyrate, the four-carbon fatty acid, is formed in the human colon by bacterial fermentation of carbohydrates (including dietary fiber), and putatively suppresses colorectal cancer (CRC). Butyrate has diverse and apparently paradoxical effects on cellular proliferation, apoptosis and differentiation that may
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