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Merck

31679

Chlorpromazine hydrochloride

VETRANAL®, analytical standard

Sinónimos:

2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil

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Fórmula empírica (notación de Hill):
C17H19ClN2S · HCl
Número CAS:
69-09-0
Peso molecular:
355.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329753883
EC Number:
200-701-3
Beilstein/REAXYS Number:
3779989
MDL number:
MFCD00012654

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Nombre del producto

Chlorpromazine hydrochloride, VETRANAL®, analytical standard

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

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Application

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.
CPZ may have been used as standard for the determination of antipsychotic drug at a glassy carbon electrode using chemometric methods, such as classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.
Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

General description

Chlorpromazine hydrochloride (CPZ) is an antipsychotic drug which belongs to phenothiazine neuroleptic group. It is used in treating mental or personality disorders.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCCN8840
BCCF9060
BCBV3536
BCBS3655V

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Voltammetric determination of chlorpromazine hydrochloride and promethazine hydrochloride with the use of multivariate calibration.
Ni, Yongnian, Li Wang, and Serge Kokot.
Analytica Chimica Acta, 439.1, 159-168 (2001)
Jessica M D'Amico et al.
Journal of neurophysiology, 109(6), 1473-1484 (2012-12-12)
In animals, the recovery of motoneuron excitability in the months following a complete spinal cord injury is mediated, in part, by increases in constitutive serotonin (5-HT2) and norepinephrine (α1) receptor activity, which facilitates the reactivation of calcium-mediated persistent inward currents
Jessica J W Broeders et al.
Toxicology in vitro : an international journal published in association with BIBRA, 27(3), 1057-1064 (2013-02-05)
The extrapolation of in vitro to in vivo toxicity data is a challenge. Differences in sensitivity between cell systems may be due to intrinsic properties of the cell but also because of differences in exposure. In this study, the cytotoxicity
Cristiane Flora Villarreal et al.
Pharmacology, biochemistry, and behavior, 103(3), 678-683 (2012-11-28)
In recent years, evidence that sensitization of primary afferent nociceptors is an important event associated with chronic pain has been accumulating. The present study aimed to evaluate the participation of the prostaglandin and sympathetic components in the long-lasting sensitization of
Sébastien Anthérieu et al.
Hepatology (Baltimore, Md.), 57(4), 1518-1529 (2012-11-24)
Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the differentiated human hepatoma HepaRG cells. Generation of reactive
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