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Merck

33114

Ácido cítrico monohydrate

ACS reagent grade, 99.5-102%, solid, puriss. p.a., reag. ISO, reag. Ph. Eur., buffer substance

Sinónimos:

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Fórmula lineal:
HOC(COOH)(CH2COOH)2 · H2O
Número CAS:
Peso molecular:
210.14
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
201-069-1
MDL number:
Beilstein/REAXYS Number:
4018641

Nombre del producto

Ácido cítrico monohydrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, 99.5-102%

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

grade

ACS reagent
puriss. p.a.

agency

USP/NF
reag. ISO
reag. Ph. Eur.

assay

99.5-100.5% (calc. on anhydrous substance)
99.5-102%

form

solid

impurities

≤0.005% insolubles in water
≤2 ppm heavy metals (as Pb)
7.5-9.0% water (Karl Fischer)

ign. residue

≤0.01% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤5 mg/kg
oxalate (C2O42-): ≤100 ppm
phosphate (PO43-): ≤10 mg/kg
sulfate (SO42-): ≤20 ppm

cation traces

Ca: ≤50 mg/kg
Cu: ≤5 mg/kg
Fe: ≤3 ppm
Pb: ≤2 ppm
Zn: ≤5 mg/kg

suitability

complies for appearance of solution
complies for reaction against H2SO4

functional group

carboxylic acid

Quality Level

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Categorías relacionadas

Application

Citric acid monohydrate may be used in the preparation of tris-citrate buffer and Otto I isolation buffer used in bioprotocols. It may also be used to improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

345.0 °F - closed cup

flash_point_c

173.9 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Determination of the Developmental Origin of Seeds Containing Endosperm Using Flow Cytometric Analysis
Sailer C, et al.
PLoS Genetics, 5(11) (2015)
Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets.
Schilling SU, et al.
International Journal of Pharmaceutics, 361(1), 158-168 (2008)
Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics.
R K Selander et al.
Applied and environmental microbiology, 51(5), 873-884 (1986-05-01)
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.

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