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Merck

46401

Cicloheximida

PESTANAL®, analytical standard

Sinónimos:

3-[2-(3,5- Dimetil-2-oxociclohexil)-2-hidroxietil]glutarimida, Actidiona, Naramicina A

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About This Item

Fórmula empírica (notación de Hill):
C15H23NO4
Número CAS:
66-81-9
Peso molecular:
281.35
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329757163
EC Number:
200-636-0
Beilstein/REAXYS Number:
88868
MDL number:
MFCD00082346

Nombre del producto

Cicloheximida, PESTANAL®, analytical standard

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

SMILES string

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

grade

analytical standard

description

mixture of stereo isomers

product line

PESTANAL®

assay

≥95% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H2O: slightly soluble

antibiotic activity spectrum

fungi

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

mode of action

protein synthesis | interferes

storage temp.

−20°C

Quality Level

100

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Categorías relacionadas

Biochem/physiol Actions

Modo de acción: inhibición de la traducción en eucariotas que provoca la detención del crecimiento celular y la muerte celular. La CHX se utiliza ampliamente para la selección de cepas de levaduras y hongos resistentes a CHX, la inhibición controlada de la síntesis de proteínas para la detección de proteínas de vida corta y la súper-inducción de la expresión de proteínas, así como la inducción de la apoptosis o la facilitación de la inducción de la apoptosis por los receptores de muerte.

Espectro de actividad: activo contra levaduras y hongos como Candida, Aspergillus, Saccharomyces y Penicillium

Application

Cycloheximide may find the following uses:
  • To evaluate the antifungal efficacy and safety of cycloheximide as a supplement in Optisol-GS
  • To study the effect of cycloheximide on leaf-cutting ant workers
  • To study the effect of streptomycin, cycloheximide, fungizone, captan, carbofuran, cygon, and pentachloronitrobenzene on soil microorganisms
  • To study the fungal control of nitrous oxide production in a semiarid grassland
  • To study the activity and degradation of streptomycin and cycloheximide in soil

General description

Cycloheximide is an antibiotic having significant antifungal properties. It is produced by streptomycin-producing strains of Streptomyces griseus and acts by inhibiting protein synthesis. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. It is used as a fungicide.
As per Regulation (EC) No 1107/2009, repealing the directive 91/414, cycloheximide is not approved for use in the European Union (EU).

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
BCCN1332
BCCM3154
BCCL9551
BCCL4263
BCCG8626

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