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Merck

D8064

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt

≥95% purity (HPLC), solid

Sinónimos:

Di-4-ANEPPS

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About This Item

Fórmula empírica (notación de Hill):
C28H36N2O3S
Número CAS:
90134-00-2
Peso molecular:
480.66
UNSPSC Code:
12171500
PubChem Substance ID:
329798855
NACRES:
NA.47
MDL number:
MFCD03453609

Nombre del producto

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt, ≥95% (HPLC), solid

SMILES string

CCCCN(CCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1

InChI key

HAPJROQJVSPKCJ-UHFFFAOYSA-N

InChI

1S/C28H36N2O3S/c1-3-5-17-30(18-6-4-2)28-13-12-26-22-25(10-11-27(26)23-28)9-8-24-14-19-29(20-15-24)16-7-21-34(31,32)33/h8-15,19-20,22-23H,3-7,16-18,21H2,1-2H3

assay

≥95% (HPLC)

form

solid

mol wt

480.66

technique(s)

titration: suitable

color

orange to dark red

solubility

DMF: soluble
DMSO: soluble
ethanol: soluble

ε (extinction coefficient)

≥38000 at 493-499 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

Quality Level

100

Categorías relacionadas

Application

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt has been used as a voltage sensitive dye in cardiac cells.

Biochem/physiol Actions

Membrane potential dye that responds to changes in membrane potential monitored by fluorescence excitation changes at 440 and 505 nm; correlated to changes in membrane potential of the cell.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
MKCT0129
MKCT0643
MKCS0172
MKCS1693
MKCS1259

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Thomas T Luyben et al.
Frontiers in neural circuits, 14, 24-24 (2020-06-26)
cAMP is a positive regulator tightly involved in certain types of synaptic plasticity and related memory functions. However, its spatiotemporal roles at the synaptic and neural circuit levels remain elusive. Using a combination of a cAMP optogenetics approach and voltage-sensitive
James E Reeve et al.
Biophysical journal, 103(5), 907-917 (2012-09-27)
Numerous dyes are available or under development for probing the structural and functional properties of biological membranes. Exogenous chromophores adopt a range of orientations when bound to membranes, which have a drastic effect on their biophysical behavior. Here, we present
Katharine M Dibb et al.
Circulation. Heart failure, 2(5), 482-489 (2009-10-08)
In ventricular myocytes, the majority of structures that couple excitation to the systolic rise of Ca(2+) are located at the transverse tubular (t-tubule) membrane. In the failing ventricle, disorganization of t-tubules disrupts excitation contraction coupling. The t-tubule membrane is virtually
Yoko Tominaga et al.
Frontiers in cellular neuroscience, 12, 389-389 (2018-11-09)
Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such
Zachary Laksman et al.
Scientific reports, 7(1), 5268-5268 (2017-07-15)
Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF for pharmacologic testing. We generated atrial-like cardiomyocytes (CMs) from hESCs which preferentially expressed atrial-specific
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