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Merck

K1637

Canamicina sulfate from Streptomyces kanamyceticus

meets USP testing specifications, powder

Sinónimos:

Canamicina A, Canamicina sulfate salt

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Fórmula empírica (notación de Hill):
C18H36N4O11 · H2O4S
Número CAS:
25389-94-0
Peso molecular:
582.58
NACRES:
NA.76
PubChem Substance ID:
24896209
UNSPSC Code:
51281654
EC Number:
246-933-9
MDL number:
MFCD00070253

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Nombre del producto

Canamicina sulfate from Streptomyces kanamyceticus, meets USP testing specifications, powder

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

biological source

Streptomyces kanamyceticus

agency

USP/NF
meets USP testing specifications

form

powder

potency

≥750 μg per mg

solubility

H2O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

application(s)

pharmaceutical (small molecule)

mode of action

protein synthesis | interferes

Quality Level

200

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Biochem/physiol Actions

Modo de acción: El producto actúa uniéndose a la subunidad ribosómica 70S, inhibiendo la translocación y provocando una codificación errónea.

Modo de resistencia: las enzimas modificadoras de los aminoglucósidos (como la acetiltransferasa, la fosfotransferasa y la nucleotidiltransferasa) pueden alterar este antibiótico y evitar su interacción con los ribosomas.

Espectro antimicrobiano: El sulfato de canamicina es eficaz contra las bacterias gramnegativas y grampositivas, y contra los micoplasmas.

Application

Kanamycin sulfate is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL. Kanamycin sulfate from Streptomyces kanamyceticus has been used: in the research of cell type-specific expression of genes

Features and Benefits

  • High quality antibiotic suitable for mulitple research applications
  • meets USP testing specifications

General description

Kanamycin Sulfate is a broad spectrum aminoglycoside-antibiotic purified from the bacterium Streptomyces kanamyceticus. Kanamycin Sulfate is a selection agent for cells in culture media and acts by binding to the 30S subunit of the bacterial ribosome which inhibits protein synthesis in susceptible bacteria.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Preparation Note

Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Clase de almacenamiento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000494665
0000494665
0000462293
0000462293
0000448270

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