N5160

Naproxen sodium

Name: Naproxen sodium
Brand: SIAL

meets USP testing specifications

Sinónimos:

(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

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About This Item

Fórmula empírica (notación de Hill):

C₁₄H₁₃NaO₃

Número CAS:

26159-34-2

Peso molecular:

252.24

NACRES:

NA.21

PubChem Substance ID:

24897724

UNSPSC Code:

41116107

EC Number:

247-486-2

MDL number:

MFCD00058507

Nombre del producto

Naproxen sodium, meets USP testing specifications

InChI key

CDBRNDSHEYLDJV-FVGYRXGTSA-M

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

SMILES string

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

agency

USP/NF
meets USP testing specifications

form

powder

application(s)

pharmaceutical (small molecule)

Quality Level

100

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Biochem/physiol Actions

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360

pcodes

P201 - P301 + P312 + P330 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1A

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Validated method for the determination of piroxicam by capillary zone electrophoresis and its application to tablets.

Arın Gül Dal et al.

Journal of analytical methods in chemistry, 2014, 352698-352698 (2014-10-09)

Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using 10 mM borate buffer (pH 9.0) containing 10%

Progestogen-only contraceptive pill compared with combined oral contraceptive in the treatment of pain symptoms caused by endometriosis in patients with migraine without aura.

Matteo Morotti et al.

European journal of obstetrics, gynecology, and reproductive biology, 179, 63-68 (2014-06-27)

Evaluate patient satisfaction at 6-month treatment in women with symptomatic rectovaginal endometriosis and migraine without aura with (progestogen-only contraceptive pill, POP versus sequential combined oral contraceptives, COC) STUDY DESIGN: A patient preference trial including 144 women (82 in the group

Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID.

Rory W Blackler et al.

American journal of physiology. Gastrointestinal and liver physiology, 308(12), G994-1003 (2015-04-18)

The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria, and enterohepatic circulation to NSAID enteropathy, using both a

A preclinical physiological assay to test modulation of knee joint pain in the spinal cord: effects of oxycodone and naproxen.

Jason A Miranda et al.

PloS one, 9(8), e106108-e106108 (2014-08-27)

Sensory processing in the spinal cord during disease states can reveal mechanisms for novel treatments, yet very little is known about pain processing at this level in the most commonly used animal models of articular pain. Here we report a

Model-based analysis of thromboxane B₂ and prostaglandin E₂ as biomarkers in the safety evaluation of naproxen.

Tarjinder Sahota et al.

Toxicology and applied pharmacology, 278(3), 209-219 (2014-03-29)

The assessment of safety in traditional toxicology protocols relies on evidence arising from observed adverse events (AEs) in animals and on establishing their correlation with different measures of drug exposure (e.g., Cmax and AUC). Such correlations, however, ignore the role

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