N9890

Norfloxacin

Name: Norfloxacin
Brand: SIAL

analytical standard, ≥98% (TLC)

Sinónimos:

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid

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About This Item

Fórmula empírica (notación de Hill):

C₁₆H₁₈FN₃O₃

Número CAS:

70458-96-7

Peso molecular:

319.33

NACRES:

NA.24

PubChem Substance ID:

329818696

UNSPSC Code:

41116107

EC Number:

274-614-4

MDL number:

MFCD00079532

Nombre del producto

Norfloxacin, analytical standard, ≥98% (TLC)

Quality Level

200

InChI key

OGJPXUAPXNRGGI-UHFFFAOYSA-N

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

grade

analytical standard

agency

EPA 1694

assay

≥98% (TLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

Gene Information

human ... CYP1A2(1544)
rat ... Gabra1(29705)

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Categorías relacionadas

Controlled Substances & Illicit Drug Standards

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Norfloxacin may be used as a standard in the determination of norfloxacin in human serum samples using fluorometric spectrophotometry.

Biochem/physiol Actions

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

General description

Chemical structure: fluoroquinolone

Norfloxacin is a broad spectrum antibiotic, which is used against a wide variety of gram positive and gram negative bacteria.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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Fluorescence reaction and complexation equilibria between norfloxacin and aluminium (III) ion in chloride medium

Djurdjevic.TP, et al.

Analytica Chimica Acta, 300, 253-259 (1995)

Evaluation of quinolones for use in detection of determinants of acquired quinolone resistance, including the new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6')Ib-cr, in Escherichia coli and Salmonella enterica and determinations of wild-type distributions.

L M Cavaco et al.

Journal of clinical microbiology, 47(9), 2751-2758 (2009-07-03)

Fluoroquinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of the topoisomerase genes. However, transferable genes encoding quinolone resistance have recently been described. The current methods for susceptibility testing are not

Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.

Deepika Sharma et al.

European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)

In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15

Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients.

Anita Reinhardt et al.

Antimicrobial agents and chemotherapy, 51(4), 1341-1350 (2007-01-31)

Intubated patients frequently become colonized by Pseudomonas aeruginosa, which is subsequently responsible for ventilator-associated pneumonia. This pathogen readily acquires resistance against available antimicrobials. Depending on the resistance mechanism selected for, resistance might either be lost or persist after removal of

Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates.

Lauren Becnel Boyd et al.

Antimicrobial agents and chemotherapy, 53(1), 229-234 (2008-10-08)

Fluoroquinolones are some of the most prescribed antibiotics in the United States. Previously, we and others showed that the fluoroquinolones exhibit a class effect with regard to the CLSI-established breakpoints for resistance, such that decreased susceptibility (i.e., an increased MIC)

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