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Merck

O0200000

Ouabain

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

Ouabain octahydrate, 1β,3β,5β,11α,14,19-Hexahydroxycard-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside), Acocantherine, G-Strophanthin

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Fórmula empírica (notación de Hill):
C29H44O12 · 8H2O
Número CAS:
11018-89-6
Peso molecular:
728.77
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329818827
MDL number:
MFCD00149240
Beilstein/REAXYS Number:
101712

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InChI key

TYBARJRCFHUHSN-DMJRSANLSA-N

SMILES string

O.O.O.O.O.O.O.O.C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O

InChI

1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-;;;;;;;;/m0......../s1

grade

pharmaceutical primary standard

API family

ouabain

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ouabain EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Meneka Kanagaratnam et al.
The Journal of physiology, 595(11), 3471-3482 (2017-02-19)
Optic nerve axons get less excitable with warming. F-fibre latency does not shorten at temperatures above 30°C. Action potential amplitude falls when the Na Raising the temperature of optic nerve from room temperature to near physiological has effects on the
Li Meng et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 1841-1848 (2016-11-30)
The steroid Na+/K+-ATPase blocker ouabain has been shown to exhibit cytotoxic effects in various tumor cell systems. This study aimed to determine the effects of ouabain on Burkitt's lymphoma Raji cells. Ouabain treatment of Raji cells significantly inhibited cell proliferation
Stephen A Adefegha et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 83, 559-568 (2016-10-25)
This study assessed the possible protective mechanisms of protocatechuic acid (PCA) against cadmium (Cd)-induced oxidative stress and neurotoxicity in rats. Male wistar strain rats weighing between 150-160g were purchased and acclimatized for two weeks. The rats were divided into seven
V Hreniukh et al.
Cell biochemistry and function, 34(8), 579-587 (2016-11-20)
The goal of the study was to estimate the effect of a selective V-type H+ -ATPase inhibitor bafilomycin A1 and nicotinic acid adenine dinucleotide phosphate (NAADP) on energetic processes in NK/Ly cell by directly measuring the respiration of isolated mitochondria
Alexander Zhyvoloup et al.
PLoS pathogens, 13(7), e1006460-e1006460 (2017-07-21)
HIV-1 integrates more frequently into transcribed genes, however the biological significance of HIV-1 integration targeting has remained elusive. Using a selective high-throughput chemical screen, we discovered that the cardiac glycoside digoxin inhibits wild-type HIV-1 infection more potently than HIV-1 bearing
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