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Merck

PHR1251

Cloruro de colina

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Cloruro de (2-hidroxietil)trimetilamonio

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About This Item

Fórmula lineal:
(CH3)3N(Cl)CH2CH2OH
Número CAS:
67-48-1
Peso molecular:
139.62
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823254
EC Number:
200-655-4
Beilstein/REAXYS Number:
3563126
MDL number:
MFCD00011721

Nombre del producto

Cloruro de colina, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

SMILES string

[Cl-].C[N+](C)(C)CCO

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1133547

API family

choline chloride

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

302-305 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Sustrato de la colina acetiltransferasa
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Choline chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3558 in the slot below. This is an example certificate only and may not be the lot that you receive.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Liquid chromatographic determination with fluorescence detection of B6 vitamers and riboflavin in milk and pharmaceuticals
Gatti R and Gioia MG
Analytica Chimica Acta, 538(1-2), 135-141 (2005)
Katherine D Weaver et al.
Biochimica et biophysica acta, 1828(8), 1856-1862 (2013-04-02)
To better understand the relationship between the relative cytotoxicity of diluted ionic liquids and their specific interaction with biological membranes, the thermotropic behavior of model lipid membrane systems formulated in a series of choline based organic salts was investigated. Unilamellar
Elisabeth Traiffort et al.
Molecular aspects of medicine, 34(2-3), 646-654 (2013-03-20)
The Na(+)-independent, high affinity choline carrier system proposed to supply choline for the synthesis of cell membrane phospholipids was recently associated with SLC44 family members (SLC44A1-5) also called choline-like transporter family. SLC44A1 is widely expressed throughout the nervous system in
Sotirios Chondrogiannis et al.
European journal of nuclear medicine and molecular imaging, 40(9), 1356-1364 (2013-05-15)
The aims of the study were (a) to evaluate the diagnostic role, by means of positive detection rate (PDR), of ¹⁸F-choline (CH) positron emission tomography (PET)/CT in patients with prostate cancer treated with radiotherapy, with curative intent, and suspicion of
Mohsen Beheshti et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(6), 833-840 (2013-04-06)
We evaluated the potential of (18)F-fluoromethyldimethyl-2-hydroxyethyl-ammonium (FCH) PET/CT in the detection of recurrent disease or distant metastases and correlated its diagnostic accuracy with prostate-specific antigen (PSA) levels in prostate cancer patients with biochemical evidence of recurrence. Furthermore, the influences of
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