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Merck

319988

Cloroformo

contains ethanol as stabilizer, ACS reagent, ≥99.8%

Sinónimos:

Triclorometano, Tricloruro de metilidino

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Fórmula empírica (notación de Hill):
CHCl3
Número CAS:
Peso molecular:
119.38
UNSPSC Code:
12191502
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1731042
Assay:
≥99.8%
Grade:
ACS reagent
Bp:
60.5-61.5 °C (lit.)
Vapor pressure:
160 mmHg ( 20 °C)
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InChI

1S/CHCl3/c2-1(3)4/h1H

SMILES string

ClC(Cl)Cl

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

grade

ACS reagent

vapor density

4.1 (vs air)

vapor pressure

160 mmHg ( 20 °C)

assay

≥99.8%

form

liquid

contains

ethanol as stabilizer

dilution

(for analytical testing)

impurities

Acetone and aldehyde, passes test, Acid and chloride, passes test, Free chlorine (Cl), passes test, H2SO4, passes test

evapn. residue

≤0.001%

color

APHA: ≤10

Quality Level

refractive index

n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

density

1.48 g/mL at 25 °C, 1.492 g/mL at 25 °C (lit.)

cation traces

Pb: ≤0.05 ppm

storage temp.

room temp

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General description

Chloroform, a halogenated hydrocarbon, is widely used as a solvent and extractant in various manufacturing and laboratory procedures. It can be produced by the chlorination of methane or lower-chlorinated methanes. Additionally, it is employed in the production of dichlorocarbenes, α-trichloromethyl carbinols, and trichlorolithiocarbenoids.
Our premium ACS solvents are ideal for routine chemical synthesis, drying, purification, and critical labware cleaning. They meet or exceed the rigorous standards of the American Chemical Society (ACS), ensuring high-quality results for your research needs.

Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.

Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.

Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.

Application

Chloroform can be used as a solvent in the:
  • Enzyme-catalyzed ring-opening polymerization of ω-pentadecalactone to prepare polyesters.
  • Pd-catalyzed cross-coupling reaction of acid chlorides with arylboronic acids to synthesize diaryl Ketones.
  • Enantio- and diastereoselective nitro-Mannich reaction of α-aryl nitromethanes with amido sulfones to synthesize β-nitroamines.
  • Diels-Alder reaction to synthesize spiro-fused dihydropyans. The hydrogen bond (CH-O) formed between chloroform and carbonyl oxygen makes the carbonyl group a stronger heterodienophile, resulting in an increased reaction rate.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Clase de almacenamiento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash


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Fabian V Filipp et al.
Pigment cell & melanoma research, 25(3), 375-383 (2012-03-01)
The tricarboxylic acid (TCA) cycle is the central hub of oxidative metabolism, running in the classic forward direction to provide carbon for biosynthesis and reducing agents for generation of ATP. Our metabolic tracer studies in melanoma cells showed that in
High activity and regenerability of a palladium-gold catalyst for chloroform degradation.
Velazquez JC, et al.
Journal of Chemical Technology and Biotechnology (2015)
Xuejun Liu et al.
Nature protocols, 2(5), 1288-1296 (2007-06-05)
A nearly quantitative 18-component synthesis of a nanocontainer, which is built up from six bowl-shaped cavitands that are connected together with 12 -CH=N-CH2CH2-N=CH- linkers, and its subsequent reduction are described. This nanocontainer has an estimated cavity volume of 1,700 A3
Yongjun Liu et al.
Journal of hazardous materials, 308, 84-90 (2016-01-26)
In this study, efficient dechlorination and decomposition of chloroform (CF) induced by glow discharge plasma (GDP) in contact with a sodium sulfate solution was investigated. Intermediate byproducts were determined by ionic chromatography and headspace gas chromatography, respectively. Results showed that
Photolysis of chloroform and other organic molecules in aqueous titanium dioxide suspensions.
Kormann C, et al.
Environmental Science & Technology, 25(3), 494-500 (1991)

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