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Merck

360589

Tetrahidrofuran

≥99.0%, ACS reagent, contains 200-400 ppm BHT as inhibitor

Sinónimos:

THF, Oxolano, Óxido de butileno, Óxido de tetrametileno

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About This Item

Fórmula empírica (notación de Hill):
C4H8O
Número CAS:
Peso molecular:
72.11
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12191501
EC Number:
203-726-8
MDL number:
Beilstein/REAXYS Number:
102391
grade:
ACS reagent
assay:
≥99.0%
technique(s):
HPLC: suitable
bp:
65-67 °C (lit.)
vapor pressure:
114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

Nombre del producto

Tetrahidrofuran, contains 200-400 ppm BHT as inhibitor, ACS reagent, ≥99.0%

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

SMILES string

C1CCOC1

grade

ACS reagent

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

assay

≥99.0%

form

liquid

autoignition temp.

610 °F

contains

200-400 ppm BHT as inhibitor

expl. lim.

1.8-11.8 %

technique(s)

HPLC: suitable

impurities

≤0.015% peroxide (as H2O2)
≤0.05% water

evapn. residue

≤0.03%

color

APHA: ≤20

refractive index

n20/D 1.407 (lit.)

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

water: soluble

density

0.889 g/mL at 25 °C (lit.)

Quality Level

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Categorías relacionadas

Application

El tetrahidrofurano (THF) se utiliza como disolvente en los siguientes procesos:

  • Síntesis orgánica
a) Grignard
b) Compuestos organometálicos
c) Reformatsky
d) Litiación
e) Reducción de hidruros
f) Acoplamiento catalizado por metales (Heck, Stile, Suzuki)
g) Reacciones mediadas por ácidos de Lewis
  • Cristalización
  • Polimerización. Ej. Polimerización RAFT (transferencia de cadena de adición-fragmentación reversible) de p-acetoxistireno.
  • Revestimientos
  • Como un ligando donante de O para formar complejos de coordinación.
  • Como disolvente de fase móvil en la cromatografía de líquidos de alta resolución.

Features and Benefits

Los disolventes ACS cumplen o superan los altos estándares de la American Chemical Society (ACS), con especificaciones analíticas especializadas para cada compuesto. Según la American Chemical Society, la calidad para reactivo ACS implica que es una sustancia de suficiente pureza como para utilizarse en la mayoría de los análisis o reacciones químicos.

General description

El tetrahidrofurano (THF) es un compuesto heterocíclico (éter cíclico). Es incoloro, tiene poca viscosidad y buena solubilidad en una amplia gama de disolventes. Se utiliza mucho como disolvente en síntesis orgánica, siendo muy popular en reacciones con compuestos organometálicos y reactivos de Grignard. Debido a la formación de peróxidos orgánicos en el almacenamiento a largo plazo, el THF suele estabilizarse añadiendo hidroxitolueno butilado (BHT). El BHT elimina los radicales libres requeridos para la formación de peróxido.
Our premium ACS solvents are ideal for routine chemical synthesis, drying, purification, and critical labware cleaning. They meet or exceed the rigorous standards of the American Chemical Society (ACS), ensuring high-quality results for your research needs.

Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.

Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.

Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup


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Mg2Si nanoparticle synthesis for high pressure hydrogenation.
Chaudhary AL, et al.
The Journal of Physical Chemistry C, 118(2), 1240-1247 (2014)
Practical Synthesis of Di-tert-Butyl-Phosphinoferrocene.
Busacca CA, et al.
Organic Syntheses, 90, 316-326 (2013)
Synthesis of NiO/TiO2 using amphiphilic diblock copolymer brushes (PMMA-b-PAA) by reversible addition fragmentation chain-transfer poltmerization.
Hojjati B and Charpentier PA.
Polymer Reviews, 50(2), 418-418 (2009)
Luca Chiari et al.
The Journal of chemical physics, 138(7), 074301-074301 (2013-03-01)
We present total, elastic, and inelastic cross sections for positron and electron scattering from tetrahydrofuran (THF) in the energy range between 1 and 5000 eV. Total cross sections (TCS), positronium formation cross sections, the summed inelastic integral cross sections (ICS)
Crispin Lichtenberg et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15797-15805 (2015-09-17)
The reactivity of the all-ferrous FeN heterocubane [Fe4 (Ntrop)4 ] (1) with i) Brønsted acids, ii) σ-donors, iii) σ-donors/π-acceptors, and iv) one-electron oxidants has been investigated (trop = 5H-dibenzo[a,d]cyclo-hepten-5-yl). 1 showed self-re-assembling after reactions with i) and proved surprisingly inert in reactions with ii)

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