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Merck

82934

7-Hydroxycitronellal

Odorant used in allergy studies

Sinónimos:

7-Hydroxy-3,7-dimethyloctanal, Citronellal hydrate

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About This Item

Fórmula empírica (notación de Hill):
C10H20O2
Número CAS:
107-75-5
Peso molecular:
172.26
NACRES:
NA.52
PubChem Substance ID:
57652938
UNSPSC Code:
12352200
EC Number:
203-518-7
MDL number:
MFCD00014681

Nombre del producto

7-Hydroxycitronellal, Odorant used in allergy studies

InChI

1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3

InChI key

WPFVBOQKRVRMJB-UHFFFAOYSA-N

SMILES string

[H]C(CC(C)CCCC(O)(C)C)=O

grade

Molecular Biology

assay

≥95.0% (GC)

form

powder

density

0.92 g/mL at 20 °C (lit.)

storage temp.

room temp

Quality Level

100

Application

Suitable for
  • contact sensitization studies to identify allergens present in cosmetic preparations
  • elucidation of molecular pathways related to allergic reactions
  • analytical standard

General description

7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
SDBB3884
SDBB2357
SDBB0781
STBL1364
STBL1767

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Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
R A Ford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(11-12), 921-926 (1988-11-01)
Hydroxycitronellal, an important ingredient in fragrances, was studied for its sensitizing potential in human skin. Fifteen human maximization tests were conducted with hydroxycitronellal obtained from four different sources at induction concentrations from 5 to 12%. No reactions were induced at
S Heydorn et al.
Contact dermatitis, 49(3), 133-139 (2003-12-18)
Household and cleaning products often contain both allergens and irritants. The aim of this double-blinded, randomized, paired study was to determine whether patch testing with an allergen (hydroxycitronellal) combined with an irritant [sodium lauryl sulfate (SLS)] cause a stronger patch
Hydroxycitronellal: A survey of consumer patch-test sensitization.
R J Steltenkamp et al.
Food and cosmetics toxicology, 18(4), 407-412 (1980-08-01)
H Wahlkvist et al.
Contact dermatitis, 41(4), 198-206 (1999-10-09)
A multi-dose-response induction protocol for the guinea pig maximization test (GPMT), including a statistical computer program, has earlier been developed to improve the power of predictive tests for identification of contact allergens. This dose-response protocol, with 2 modifications (i.e., increased
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