A4612
Seroalbúmina bovina
lyophilized powder, Essentially fatty acid free
Sinónimos:
Albúmina bovina, Albúmina sérica bovina, BSA
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About This Item
Nombre del producto
Seroalbúmina bovina, lyophilized powder, Essentially fatty acid free
biological source
bovine
assay
≥98% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
~66 kDa
packaging
poly bottle of
origin
New Zealand origin
technique(s)
ELISA: suitable
cell culture | mammalian: suitable
impurities
≤0.01% free fatty acid (GC)
pH
4.8-7.5
solubility
H2O: soluble 40 mg/mL
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
bovine ... ALB(280717)
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Categorías relacionadas
Biochem/physiol Actions
Se sospecha que ciertos epítopos conformacionales y de secuencia primaria son alérgenos en las alergias humanas a la leche y a la carne.
Albumin is the most important circulatory protein involved in the control of Ca2+ (and Mg2+) levels in mammals.
Bovine Serum Albumin (BSA) is a transporter for drugs, hormones and fatty acids. It is used as a blocking agent in enzyme linked immunosorbent assay (ELISA) for preventing non-specific binding of antigens and antibodies to the microtiter plates. BSA is a crucial component of the cell culture media and favors embryonic stem cells (hESC) differentiation. BSA shares structural features with human serum albumin. Its high solubility, low cost and purity and interaction with surfactant is exploited in cosmetic and pharmaceutical industry.
Preparation Note
La seroalbúmina puede denominarse también Fracción V. Esta convención de nomenclatura procede del método original de fraccionamiento de las proteínas séricas de Cohn en el que se utiliza precipitación en etanol frío. Utilizando dicho método, la seroalbúmina se encontró en la fracción quinta del etanol. Desde entonces, algunos han venido utilizando la expresión «Fracción V» para describir la albúmina sérica, al margen del método de preparación. Otros han utilizado este término para describir la seroalbúmina purificada por métodos de fraccionamiento en etanol que se han modificado mucho desde que se describió el método Cohn original. Sigma-Aldrich fabrica y distribuye seroalbúminas purificadas mediante una variedad de métodos primarios, entre ellos el verdadero método de fraccionamiento de Cohn, los métodos de fraccionamiento en etanol modificados, el fraccionamiento térmico y la cromatografía. Etapas de purificación añadidas pueden ser la cristalización o la filtración en carbón activado.
Application
Bovine Serum Albumin has been used as a component of Tris-buffered saline (TBST) to stabilize polyvinylidene fluoride (PVDF) membranes during western blotting. It has also been used in along with phosphate-buffered saline with tween detergent (PBST) as a blocking buffer in enzyme linked immunosorbent assay(ELISA).
Bovine serum albumin (BSA) is extensively used for drug delivery since it is widely available, cheap and easily purified, has ligand-binding properties, and is widely accepted in the pharmaceutical industry.
Features and Benefits
- Essentially fatty acid-free
- Sourced and manufactured in New Zealand
- Prepared by chromatography
General description
Bovine serum albumin (BSA) is an α-helical, globular and non-glycosylated 66kDa protein. It is characterized with three domains with two subdomains under each. BSA belongs to the serum albumins family and has 17-disulfide bonds.
The most abundant plasma protein in mammals is albumin. It is produced in the liver and transferred as a non-glycosylated protein into the plasma. This multifunctional protein has an amazing ability to bind to ligands.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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