A7506

Ácido L-ascórbico

Name: <SC>Ácido L</SC>-ascórbico
Brand: SIGMA

reagent grade, crystalline

Sinónimos:

Ácido L-treoascórbico, Factor antiescorbútico, Vitamina C

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About This Item

Fórmula empírica (notación de Hill):

C₆H₈O₆

Número CAS:

50-81-7

Peso molecular:

176.12

UNSPSC Code:

12352209

NACRES:

NA.26

PubChem Substance ID:

24891246

EC Number:

200-066-2

Beilstein/REAXYS Number:

84272

MDL number:

MFCD00064328

Nombre del producto

Ácido L-ascórbico, reagent grade, crystalline

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

biological source

synthetic

grade

reagent grade

assay

≥98% ( with iodine, titration)

form

crystalline

technique(s)

HPLC: suitable
cell culture | stem cell: suitable

color

white to slightly yellow

pH

1.0-2.5 (25 °C, 176 g/L in water)

mp

190-194 °C (dec.)

solubility

water: soluble 50 mg/mL

storage temp.

room temp

Quality Level

200

Gene Information

human ... SLC23A2(9962)

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Categorías relacionadas

Coenzimas

Suplementos y reactivos para cultivo celular

Vitaminas

Application

L-Ascorbic acid has been used:

as a chondrogenic medium component for culturing bone-derived mesenchymal stem cells (BMSCs)(149)
as a reference standard in high-performance liquid chromatography system (HPLC)(150)
to test its effect on human gastric cancer GES-1 and AGS cells(151)

Biochem/physiol Actions

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

L-Ascorbic acid deficiency is associated with lack of L-gulono-1,4-lactone oxidase (GLO) enzyme. It elicits antioxidant functionality and gets oxidized to dehydroascorbate via ascorbyl radical intermediate. L-Ascorbic acid is essential for maintaining the redox balance. It is a cofactor for dopamine-β-hydroxylase and favors T cell proliferation, protects immune system and provides relief in common cold.

Disclaimer

May darken in storage.

General description

L-Ascorbic acid biosynthetic pathway varies in plants, animals and fungi. It is synthesized from L-gulono-1,4-lactone by the action of enzyme L-gulono-1,4-lactone oxidase (GLO).

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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Vitamin C in health and disease: its role in the metabolism of cells and redox state in the brain

Figueroa-Mendez R and Rivas-Arancibia, S

Frontiers in Physiology, 6, 397-397 (2015)

L-Ascorbic acid in organic synthesis: an overview

Tripathi RP, et al.

Current Organic Chemistry, 13(1), 99-122 (2009)

Vitamin C in disease prevention and cure: an overview

Chambial S, et al.

Indian Journal of Clinical Biochemistry : IJCB, 28(4), 314-328 (2013)

Nitric oxide activates TRP channels by cysteine S-nitrosylation.

Takashi Yoshida et al.

Nature chemical biology, 2(11), 596-607 (2006-09-26)

Transient receptor potential (TRP) proteins form plasma-membrane cation channels that act as sensors for diverse cellular stimuli. Here, we report a novel activation mechanism mediated by cysteine S-nitrosylation in TRP channels. Recombinant TRPC1, TRPC4, TRPC5, TRPV1, TRPV3 and TRPV4 of

Ocean plankton. Patterns and ecological drivers of ocean viral communities.

Jennifer R Brum et al.

Science (New York, N.Y.), 348(6237), 1261498-1261498 (2015-05-23)

Viruses influence ecosystems by modulating microbial population size, diversity, metabolic outputs, and gene flow. Here, we use quantitative double-stranded DNA (dsDNA) viral-fraction metagenomes (viromes) and whole viral community morphological data sets from 43 Tara Oceans expedition samples to assess viral

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Product Information Sheet - A7506

Product Information Sheet

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