A8381
L-Asparragina monohydrate
≥99% (TLC)
Sinónimos:
4-Amida del ácido(S)-2-aminosuccínico, 4-Amida del ácido L-aspártico, Ácido (S)-(+)-2-aminosuccinámico
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Fórmula lineal:
NH2COCH2CH(NH2)COOH · H2O
Número CAS:
Peso molecular:
150.13
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
200-735-9
MDL number:
Beilstein/REAXYS Number:
1723527
Servicio técnico
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Permítanos ayudarleNombre del producto
L-Asparragina monohydrate, ≥99% (TLC)
biological source
synthetic
Quality Level
assay
≥99% (TLC)
form
powder
color
white to off-white
mp
233-235 °C (lit.)
application(s)
cell analysis
peptide synthesis
SMILES string
[H]O[H].N[C@@H](CC(N)=O)C(O)=O
InChI
1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
InChI key
RBMGJIZCEWRQES-DKWTVANSSA-N
General description
Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues. Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt. It is also present in senescing leaves and germinating seeds.
Application
L-Asparagine monohydrate has been used:
- as a component of Sauton′s and chelated Sauton′s media for mycobacterial growth
- to test its effect in the induction of Ca2+ flux in rice roots using aequorin luminescence imaging
- as a component of fermentation medium for the Blakeslea trispora spores
Biochem/physiol Actions
L-Asparagine, a proteinogenic amino acid, is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies and in cell culture based research.
Asparagine has high nitrogen to carbon ratio and is a key regulator for nitrogen storage and transport. Its thermal degradation in the presence of sugars leads to the acrylamide formation in foods. Asparagine serves as an amino acid exchange factor and is essential for amino acid homeostasis. It favors cancer cell proliferation.
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Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenido relacionado
Product Information Sheet
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
Krall AS, et al.
Nature Communications, 7(1), 11457-11457 (2016)
Heterologous expression and functional analysis of rice GLUTAMATE RECEPTOR-LIKE family indicates its role in glutamate triggered calcium flux in rice roots
Ni J, et al.
Rice (New York, N.Y.), 9(1), 9-9 (2016)
Asparagine Synthesis
The Enzymes, 10, 561-580 (1974)