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Merck

B1502

Brain Extract from bovine brain

Type I, Folch Fraction I

Sinónimos:

Brain Extract from Bovine

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NACRES:
NA.25
UNSPSC Code:
12352211
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biological source

bovine brain

Quality Level

type

Type I

form

powder

lipid type

phosphoglycerides

storage temp.

−20°C

General description

Brain extract has lipids, especially polyunsaturated fatty acids (PUFAs) at high level. Extract from substantia niagra and the striatum has high amount of iron.

Application

Brain Extract from bovine brain has been used:
  • to prepare small unilamellar vesicles
  • in lipid binding assay
  • to aid the recovery of phosphoinositides and also to terminate the reaction in phosphatidylinositol 5-phosphate (PtdIns5P) and PtdIns4P assay
  • in liposome and protein self-aggregation assays

Biochem/physiol Actions

Brain lipids are involved in cellular signal transduction, membrane organization, trafficking protein modification, interactions and energy storage.

Packaging

Sealed ampule.

Other Notes

Contains phosphatidylinositol phosphatidylserine,other brain lipids.


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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers
Low C, et al.
Biophysical Journal, 95(9), 4315-4323 (2008)
Ina Ammendrup-Johnsen et al.
Biochemistry, 51(2), 586-596 (2011-12-02)
PICK1 (protein interacting with C kinase 1) contains an N-terminal protein binding PDZ domain and a C-terminal lipid binding BAR domain. PICK1 plays a key role in several physiological processes, including synaptic plasticity. However, little is known about the cellular
Anand Kumar Pandey et al.
International review of neurobiology, 102, 107-146 (2012-07-04)
Oxidative stress in the central nervous system is one of the key players for neurodegeneration. Thus, antioxidants could play important roles in treating several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and aging-related brain disorders. This review is focused on