C0768

Cyclophosphamide monohydrate

Name: Cyclophosphamide monohydrate
Brand: SIGMA

97.0-103.0% (HPLC), Alkylating agent, powder

Sinónimos:

2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Todas las fotos(8)

About This Item

Fórmula empírica (notación de Hill):

C₇H₁₅Cl₂N₂O₂P · H₂O

Número CAS:

6055-19-2

Peso molecular:

279.10

NACRES:

NA.77

PubChem Substance ID:

57653979

UNSPSC Code:

51112507

EC Number:

200-015-4

MDL number:

MFCD00149395

Beilstein/REAXYS Number:

4678992

Nombre del producto

Cyclophosphamide monohydrate, bulk package

InChI key

PWOQRKCAHTVFLB-UHFFFAOYSA-N

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

SMILES string

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

assay

97.0-103.0% (HPLC)

form

powder

mp

49-51 °C (lit.)

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ALDH1A1(216), ALDH1B1(219)

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

Bioactive Small Molecules

Application

Cyclophosphamide monohydrate has been used:

to test its antitumor effect on TC-1 tumor cells
as a component of multidrug solution for isolation of resistant human burkitt lymphoma cell line
in testing antitumor immunity in mouse tumor cell lines

Biochem/physiol Actions

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Cyclophosphamide (CYC) is a cytotoxic alkylating agent. It is activated by the cytochrome P-450 enzyme system in the liver. It has immunomodulatory functionality and inhibits humoral and cellular immunity.Cyclophosphamide exhibits anti-cancer and immunosuppressant activities. In the body, cyclophosphamide is converted by the liver to an active alkylating 4-hydroxycyclophosphamide metabolite, thereby showing its anti-neoplastic effects.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H340,H350,H360FD

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.

J Tammam et al.

British journal of pharmacology, 158(5), 1183-1195 (2009-09-25)

gamma-Secretase inhibitors (GSIs) block NOTCH receptor cleavage and pathway activation and have been under clinical evaluation for the treatment of malignancies such as T-cell acute lymphoblastic leukaemia (T-ALL). The ability of GSIs to decrease T-ALL cell viability in vitro is

STAT3 mediates multidrug resistance of Burkitt lymphoma cells by promoting antioxidant feedback

Zeng R, et al.

Biochemical and biophysical research communications, 488(1), 182-188 (2017)

Cyclophosphamide

Ogino MH, et al.

JAK-STAT Pathway in Disease (2020)

A tritherapy combination of inactivated allogeneic leukocytes infusion and cell vaccine with cyclophosphamide in a sequential regimen enhances antitumor immunity

Tang Y, et al.

Journal of the Chinese Medical Association : JCMA, 81(4), 316-323 (2018)

Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c mice

Huyan XH, et al.

International Immunopharmacology, 11(9), 1293-1297 (2011)

Ver todos los artículos relacionados

Contenido relacionado

Product Information Sheet - C0768

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico