C174
Corticosterone: HBC complex
≥91.5% (HPLC), free flowing powder, water-soluble stress hormone
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Permítanos ayudarleNombre del producto
Corticosterone: HBC complex, free flowing powder
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
assay
≥91.5% (HPLC)
form
free flowing powder
shipped in
ambient
storage temp.
room temp
SMILES string
O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
InChI
1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Application
Corticosterone: HBC complex has been used:
- in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
- to induce acute stress in mice
- in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription
Biochem/physiol Actions
The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.
Preparation Note
Corticosterone content: 66.7 mg/g. When 1 g of complex is reconstituted with water to a total volume of 2.12 mL, a solution which is 90.8 mM in corticosterone is obtained. Corticosterone itself is virtually insoluble in water.
Other Notes
Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclodextrin. Package size is total weight of both the corticosterone and the 2-hydroxypropyl-β-cyclodextrin. Corticosterone content: 66.7 mg/g
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Jan Kroon et al.
Molecular metabolism, 47, 101179-101179 (2021-02-07)
Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the rhythm of triglyceride-derived fatty acid (FA) uptake by BAT, we investigated
Marlena Wosiski-Kuhn et al.
Psychoneuroendocrinology, 42, 165-177 (2014-03-19)
Diabetes and obesity are associated with perturbation of adrenal steroid hormones and impairment of hippocampal plasticity, but the question of whether these conditions recruit glucocorticoid-mediated molecular cascades that are comparable to other stressors has yet to be fully addressed. We
CORT, Cort, B, Corticosterone, and now Cortistatin: Enough Already!
Hershel Raff
Endocrinology, 157(9), 3307-3308 (2016-07-29)