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Merck

C9672

Monoclonal Anti-Neural Cell Adhesion Molecule antibody produced in mouse

clone NCAM-0B11, ascites fluid

Sinónimos:

Anti-CD56-CY, Anti-NCAM

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UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00164707

Documentos clave

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Nombre del producto

Monoclonal Anti-Neural Cell Adhesion Molecule antibody produced in mouse, clone NCAM-0B11, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

NCAM-0B11, monoclonal

mol wt

antigen 140-180 kDa

contains

15 mM sodium azide

species reactivity

rat, human

technique(s)

immunocytochemistry: suitable using cells and tissues
western blot: 1:100 using a freshly prepared extract from newborn and adult rat brain, or rat cerebral cortex extract

isotype

IgG1

UniProt accession no.

O15394
P13591

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... NCAM1(4684), NCAM2(4685)
rat ... Ncam1(24586), Ncam2(288280)

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (3 papers)
Monoclonal Anti-Neural Cell Adhesion Molecule antibody produced in mouse has been used in:
  • Immunofluorescence
  • Immunohistochemistry
  • Immunoblotting

Biochem/physiol Actions

Neural cell adhesion molecule (N-CAM) are believed to be involved in cell-cell interactions and probably play an important role in embryogenesis and development.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-N-CAM (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Neural cell adhesion molecule (N-CAM), the best characterized CAM, exists in adult brain. It belongs to the family of sialoglycoproteins, which arise from alternative splicing of mRNA transcribed from a single gene. Immunocytochemical data indicate that in the adult, N-CAM is expressed mainly in cells of the nervous system. There are indications that N-CAM may also be expressed by non-neural cells in the adult, as it has been found in studies of various embryonic developmental stages.
Mouse monoclonal clone NCAM-0B11 anti-Neural Cell Adhesion Molecule antibody localizes the high molecular weight isoform of N-CAM (neural cell adhesion molecule) in human and several other mammalian species. The antibody shows a strong reaction to N-CAM A/N-CAM 180, however it also recognizes N-CAM B/N-CAM 140. In an immunoblot, the product reacts with polysialated N-CAM in embryonic material. Breakdown products of N-CAM may be stained; they appear as bands lower than 100 kD on the immunoblot.

Immunogen

growth cone enriched plasma membrane fraction from E17 rat forebrain.

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Clase de almacenamiento

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000512398
0000512398
0000483560
0000483560
0000422544

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The ubiquitous neural cell adhesion molecule (N-CAM)
Weledji EP and Assob JC
Annals of medicine and surgery, 3(3), 77-81 (2014)
Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with
Huang L, et al.
Neoplasia, 18(2), 71-81 (2016)
Expression and localization of neural cell adhesion molecule and polysialic acid during chick corneal development
Mao X, et al.
Investigative Ophthalmology & Visual Science, 53(3), 1234-1243 (2012)
Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner
Chi L et al.
Testing, 8(6), e65448-e65448 (2013)
Neural cell adhesion molecule (NCAM) isoform expression is associated with neuroblastoma differentiation status
Winter C, et al.
Pediatric Blood & Cancer, 51(1), 10-16 (2008)
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