D7810

Anti-Daxx antibody produced in rabbit

Name: Anti-Daxx antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

Sinónimos:

Anti-BING2, Anti-DAP6, Anti-EAP1, Anti-SMIM40

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01865517

Nombre del producto

Anti-Daxx antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 120 kDa

species reactivity

mouse, human, monkey

technique(s)

microarray: suitable
western blot: 1:4,000 using human acute lymphoma Jurkat whole cell extract

UniProt accession no.

Q9UER7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Application

Anti-Daxx antibody is suitable for:

western blot (1:4,000 using human acute lymphoma Jurkat whole cell extract)
microarray
the detection and localization of Daxx by immunoblotting

Anti-Daxx antibody produced in rabbit has been used to visualize hDaxx.

Biochem/physiol Actions

Anti-Daxx specifically recognizes human Daxx (120 kDa).

The death domain-associated protein (Daxx) is a protein that interacts with FAS and subsequently regulates cellular apoptosis. Daxx also interacts with H3.3 histone and α-thalassemia X-linked mental retardation protein (ATRX) to regulate chromatin deposition at telomeres. In addition, it also acts as a pro-apoptotic molecule that can specifically enhance Fas-induced apoptosis by activating the Jun N-terminal kinase (JNK) signaling pathway, through its interaction with the apoptosis signal-regulating kinase 1 (ASK1).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Death domain associated protein (Daxx), also known as ETS associated protein 1 (EAP1), is an adaptor protein that binds to the death domain of Fas. Daxx is a 120 kDa protein with a nuclear localization signal sequence. It is highly acidic due to extended glutamic acid-rich domains. Daxx mRNA is extensively expressed in fetal and adult human and mouse tissues. Daxx has also been found in the nucleus where it localizes with the promyelocytic leukemia protein (PML), a gene of acute promyelocytic leukemia (APL).

Immunogen

Synthetic peptide corresponding to the C-terminus of human Daxx. This sequence is identical in mouse and monkey.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number

0000415587

0000417622

0000354892

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The replication defect of ICP0-null mutant herpes simplex virus 1 can be largely complemented by the combined activities of human cytomegalovirus proteins IE1 and pp71

Everett RD, et al.

Journal of virology, 87(2), 978-990 (2013)

Daxx is an H3. 3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

Lewis P, et al.

Proceedings of the National Academy of Sciences of the USA, 107(32), 14075-14080 (2010)

DAXX modulates human papillomavirus early gene expression and genome replication in U2OS cells.

Piia Kivipõld et al.

Virology journal, 12, 104-104 (2015-07-08)

The human papillomavirus (HPV) genomes can replicate, and are maintained as autonomously replicating extrachromosomal plasmids in human U2OS cells. Previous studies have shown that HPV genomes are transcriptionally active in U2OS cells and can express the viral early proteins required

Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity

Ecsedy JA, et al.

Molecular and Cellular Biology, 23(3), 950-960 (2003)

Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis

Zhong S, et al.

The Journal of Experimental Medicine, 191(4), 631-640 (2000)

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Data Sheet - D7810

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