モノクロナール抗エラスチン マウス宿主抗体

Monoclonal Anti-Elastin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Elastin is an important polymeric protein of connective tissue. It is synthesized and secreted as a soluble single-chain protein (tropoelastin) that undergoes numerous post-ribosomal modifications prior to the organization of the elastic fiber in the extracellular space.

ウシα-エラスチン

Monoclonal Anti-Elastin antibody produced in mouse has been used in:

• immunohistochemistry
• immunostaining
• immunoblotting

本抗体は不溶性エラスチン、α-エラスチン、トロポエラスチン (エラスチンの非架橋可溶性前駆体) 、不溶性エラスチンのタンパク質分解で生じるペプチドフラグメントに結合します。トロポエラスチ調製物の場合、エラスチンの3つのアイソフォ-ムに対応する3本のバンド (67.5kDa, 65kDa, 62kDa) を検出します。この抗体はエラスチンの繰返し配列から構成されるエピト-プ (Val-Gly-Val-Ala-Pro-Gly) に特異的です。このエピト-プは線維芽細胞および単球に対する化学誘引物質であることが示されています。

Elastin is encoded by the ELN gene in humans. It is a polymeric protein in connective tissue that has exceptional properties of extension, elastic recoil to the extracellular matrix and allows many tissues in the body to resume their shape after stretching or contracting. Elastin is a self-assembling, extracellular-matrix protein providing tissue elasticity and is predominantly comprised of cross-linked tropoelastin. It plays an important role in the atherosclerotic process. The conformational disorder is caused due to a constitutive feature of elastin structure and function.

Elastin undergoes changes of morphology with aging and in many disease states. For example, abnormal accumulation of connective tissue in blood vessels contributes to alterations in vascular physiology associated with diseases such as hypertension and atherosclerosis. Several heritable diseases such as Marfan syndrome, pseudoxanthoma elasticum and the Buschke-Ollendorf syndrome may result from molecular defects of elastin.

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